Relationship of Goblet Cell Density and Glaucoma Filtration Surgery Outcome

We congratulate Agnifili and colleagues¹ for their study analyzing the relationship between goblet cell density and the outcome of glaucoma filtration surgery. They found that a higher preoperative goblet cell density was associated with a higher success rate. A previous study reported significant negative correlations between age and goblet cell density.² However, our experience and the results of other studies showed that the success rate for glaucoma filtration surgery is higher in older than in younger patients.³ Thus, in addition to goblet cell density, other important factors appear to influence the surgery outcome. Further analysis (e.g., logistic regression) should be performed in their study to determine which of these factors is most relevant.