This study adhered to the tenets of the Declaration of Helsinki and had research ethics committee approval (REC: 13/LO/1084). Patients and relatives, where available, with a clinical diagnosis of RBCD, TBCD, LCD, GCD, or EBMD were examined at Moorfields Eye Hospital by a clinician experienced in inherited and acquired corneal disease (SJT). Data collected included family history, medical history, age of onset, and previous ocular surgery (e.g., keratoplasty, phototherapeutic keratectomy). Affected individuals had photographic documentation of their corneal changes. Patients with EBMD were included if they were bilaterally affected with subepithelial lines, cysts, or geographic opacities without a history of prior traumatic corneal abrasion. For patients who had keratoplasties, histology was performed for confirmation of affected disease status.