November 2016
Volume 57, Issue 14
Open Access
Research Highlight  |   November 2016
Diurnal Fluctuation of Intraocular Pressure
Author Affiliations
  • Paul L. Kaufman
    Department of Ophthalmology & Visual Sciences, School of Medicine & Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States;
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6427. doi:
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      Paul L. Kaufman; Diurnal Fluctuation of Intraocular Pressure. Invest. Ophthalmol. Vis. Sci. 2016;57(14):6427. doi:

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      © ARVO (1962-2015); The Authors (2016-present)

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Diurnal fluctuation of intraocular pressure (IOP) is an important issue in managing glaucoma, yet its bases are not well understood. Delineating the genetic controllers and physiological pathways may open the door to potential therapeutic targets. Miller and associates1 have provided evidence for a GPR18 role in the diurnal regulation of IOP in mice and explored the related endocannabinoid pathways. Albeit early in the game, the article is a noteworthy step in unraveling the mysteries of diurnal IOP variation, a phenomenon of considerable clinical importance. 
Miller S, Leishman E, Oehler O, et al. Evidence for a GPR18 role in diurnal regulation of intraocular pressure. Invest Ophthalmol Vis Sci. 2016; 57: 6419– 6426.

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