Table 3 shows the CT and ST in eyes with and without severe MMD. Subfoveal CT was significantly thinner in eyes with severe MMD (31.5 ± 40.5 μm versus 82.0 ± 57.1 μm,
P < 0.001). The superior, inferior, nasal, and temporal CT were thinner in eyes with severe MMD, but the difference was not statistically significant. Scleral thickness was thinner in all positions, but none of these reached statistical significance.
We further evaluated the correlation between MMD severity and ST, and between MMD severity and CT (
Table 4). Choroidal thickness, in particular subfoveal CT, was strongly correlated with MMD severity based on META-PM classification (
r = −0.70,
P < 0.001). Subfoveal ST was also correlated with MMD severity (
r = −0.31,
P = 0.01), but the correlation was weaker than that between CT and MMD severity. In addition, both subfoveal CT and subfoveal ST had moderate correlation with AL and weak correlation with BCVA. There was weak correlation between subfoveal CT and subfoveal ST (
r = 0.30,
P = 0.02).
Multivariable analysis adjusted for age, gender, and correlation between left and right eyes of the same patient showed an independent association between subfoveal CT, but not subfoveal ST, with the presence of MMD (odds ratio [OR] per 10 μm decrease in CT 1.41, 95% confidence interval [CI] 1.13–1.76, P = 0.002, and OR per 10 μm decrease in ST 0.99, 95% CI 0.89–1.11, P = 0.90). In addition, we repeated the multivariable analysis after excluding eyes in which measurements of the subfoveal ST were confounded by the presence of posterior ciliary arteries and/or episcleral fibers. In this analysis, subfoveal CT remained significantly associated with the presence of MMD (OR per 10 μm decrease in CT 1.88, 95% CI 1.18–3.01, P = 0.008, and OR per 10 μm decrease in ST 1.08, 95% CI 0.89–1.32, P = 0.42).