Purchase this article with an account.
Chen-Jin Jin, Kunbei Lai, Lijun Zhou, Shanshan Yu, Chuangxin Huang, Xiaojing Zhong, Lu Lin; Difference between polypoidal choroidal vasculopathy and age-related macular degeneration in spectral domain OCT: from the perspective of choroidal vascular architecture. Invest. Ophthalmol. Vis. Sci. 2017;58(8):45.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To investigate the differences of choroidal vascular architecture in spectral domain optical coherence tomography (SD-OCT) between polypoidal choroidal vasculopathy (PCV) and neovascular AMD (nAMD) patients.
SD-OCT images in 189 eyes (189 patients) with macula-involved PCV (n=107) and nAMD (n=82) were reviewed retrospectively. The subfoveal choroidal thickness including the choriocapillaris/medium choroidal vessel layer and the large choroidal vessel layer (the Haller layer), as well as the mean maximum diameters of large choroidal vessel under macular were measured and compared between two groups.
The total subfoveal choroidal thickness of the PCV group and the nAMD group were 257.31±100.50μm and 209.95±97.51μm, respectively (P<0.01). And the ratio of subfoveal large choroidal vessel layer thickness/total choroidal thickness (0.83±0.07) in the PCV group was significantly higher than that in nAMD group (0.75±0.11) (P<0.01). Similar results were found in the mean maximum diameters of large choroidal vessel between two groups (163.55±62.23μm vs. 112.81±58.87μm) (P<0.01).
Choroidal thickening (pachychoroid), as well as vasodilation of the Haller layer were significantly more common in PCV patients than that in nAMD patients, suggesting that PCV and AMD might be two different entities, at least from the perspective of choroidal vascular architecture.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
This PDF is available to Subscribers Only