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Galina Dimitrova, Etsuo Chihara, Hiroyuki Takahashi, Hiroyuki Amano, Kazushiro Okazaki; SD OCT and OCT angiography parameters in the optic nerve head and peripapillary tissue of diabetic patients without diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2017;58(8):68.
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© ARVO (1962-2015); The Authors (2016-present)
To compare spectral domain optical coherence tomography (SD OCT) and OCT angiographic parameters in the optic nerve head and peripapillary tissue between control subjects and diabetic patients without diabetic retinopathy (NDR). To study associations between OCT angiography parameters, peripapillary and optic nerve head structure parameters and systemic characteristics in all subjects.
Sixty patients were included in the study: control subjects (n=31), patients with NDR (n=29). Exclusion criteria: conditions that may affect retinal and choroidal blood circulation (glaucoma, diabetic or non-diabetic retinopathy, age-related macular degeneration, uveitis, etc.) patients with intraocular surgery and retinal photocoagulation. OCT angiographic parameters: vessel density (VD) (%) (radial peripapillary retinal capillary plexus and choriocapillaris). SSADA software algorithm was used for evaluation of vessel density. SD OCT was used to assess macular global loss volume (GLV), focal-loss volume (FLV), peripapillary retinal nerve fibre layer thickness (RNFLT), ganglion cell complex (GCC) and optic nerve head parameters: cup-disk ratio, rim area, cup area, disk area.
There were no significant differences in the SD OCT and OCT angiography parameters between the control group and the patients with NDR. In the control group there was a significant association between FLV and radial peripapillary VD (r=-0.44, p=0.02) and choroidal VD (r=-0.59, p<0.001). Age was also significantly correlated with radial peripapillary VD (r=-0.54, p=0.002) in the control group. In the NDR group there was a significantly negative association between GCC and choriocapillary VD (r=-0.46, p=0.01). Radial peripapillary VD had a negative correlation with ocular perfusion pressure in this group (r=-0.42, p=0.02). OCT angiography signal strength was positively correlated with radial peripapillary VD and choriocapillary VD in both control (r=0.79, p<0.001; r=0.38, p=0.04) and in the NDR group (r=0.78, p<0.001; r=0.61, p<0.001).
Associations between OCT angiography VD in the peripapillary retina and in the choriocapillaries with SD OCT parameters and with subject’s clinical characteristics differ between control subjects and patients with NDR.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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