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Luigi Capone, Alessandro Rabiolo, Maria Vittoria Cicinelli, Eleonora Corbelli, Giovanni Baldin, Adriano Carnevali, Rosangela Lattanzio, Lea Querques, Giuseppe Querques, Francesco Bandello; CORRELATION ANALYSIS BETWEEN FOVEAL AVASCULAR ZONE AND PERIPHERAL ISCHEMIC INDEX IN DIABETIC RETINOPATHY: A PILOT STUDY. Invest. Ophthalmol. Vis. Sci. 2017;58(8):74.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the foveal avascular zone (FAZ) by optical coherence tomography angiography (OCT-A) in patients affected by diabetic retinopathy (DR) and its correlation with peripheral retinal ischemic index (ISI).
All patient underwent a comprehensive ocular examination including optical coherence tomography (OCT), OCT-A, ultra-widefield (UWF) retinography and UWF fluorescein angiography.
Twenty-one eyes of 14 patients (7 males, mean age 56.1 ± 14.4 years) were included. Mean ftFAZ, sFAZ and dFAZ areas were 0.320 ± 0.130 mm2, 0.325 ± 0.162 mm2 and 0.840 ± 0.329 mm2, respectively. Mean ISI was 14.6 % (range 0%-49.7%). A significant correlation was found between ISI and both ftFAZ (p = 0.0065) and sFAZ (p = 0.0052). DR grading correlated to ISI (p = 0.0053), ftFAZ (p = 0.0106), and sFAZ (p = 0.0119) areas. No significant correlation between ISI and dFAZ was appreciated. BCVA correlated to no variable other than CMT (p = 0.0003).
The association between peripheral and macular perfusion found in this study supports the hypothesis that both these condition share a common pathogenic mechanism that is capillary non-perfusion
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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