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Naoko Kakiuchi, Shozo Sonoda, Takehiro Yamashita, Hideki Shiihara, Naoya Yoshihara, Yuya Kii, Nobuhiro Kuroiwa, Narimasa Yoshinaga, Taiji Sakamoto; Regional difference of choroidal structure on OCT image. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1297.
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© ARVO (1962-2015); The Authors (2016-present)
To analyze the choroidal structure and its location using enhanced depth imaging (EDI-OCT) technique in normal eyes.
The right eyes of healthy volunteers were examined by EDI-OCT (Spectralis®) using a 55 degree lens. The cross-sectional area of choroid, luminal area, and stromal area was quantitatively evaluated by our previous method using binarization technique with our original software. Then the ratio of luminal area of the whole choroid was calculated. To see the regional difference in posterior eye, the choroid was segmented into 2 sectors. The circular area with 3,000 μm diameter from fovea (macula area) and the surrounding circular area with 8,000 μm diameter (peri-macula area). Next, these areas were further divided into the upper and the lower sectors by the foveo-papillar line. Thus, posterior choroid was divided into four sectors. The upper sector was compared with its lower counterpart sector.
Clear choroidal OCT images were obtained from 26 eyes (16 male eyes) with the average age of 34.27 years. Axial length was 25.03 mm in average. In comparison of the upper and the lower sectors, total cross sectional choroid of macula area, including luminal area and stromal area was significantly smaller in the lower sectors than the upper counterpart (P=0.002, 0.005, and 0.001, respectively). The ratio of luminal area was also smaller in the lower than upper sector (P=0.03). In peri-macula area, total cross sectional choroid of macula area, including luminal area and stromal area was also significantly smaller in the lower area than the upper counterpart (P<0.05, all). The ratio of luminal area was also smaller in the lower than the upper sector.
The choroidal area of posterior eye was larger in the upper part than the lower part. Although, both stromal and the luminal areas were smaller in the lower area than the upper area, the ratio of luminal area was significantly smaller in the lower part. Because luminal area supposedly represents the vascular lumen, the vascular system may be less developed in the lower choroid. This might be something to do with that the lower choroid is the region where optic cup fissula closes in embryonic stage.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
Figure legend. Representative data processing of EDI-OCT image by our software. Top: Stromal and luminal area of choroid is delineated automatically. Middle: These area is binarized. Bottom: The size of stromal or lumen area is calculated separately.
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