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Kazuhiko Mori, Ayumi Miura, Junta Kubo, Yuji Yamamoto, Kengo Yoshii, Yoko Ikeda, Morio Ueno, Kojiro Imai, Noriko Koizumi, Shigeru Kinoshita, Chie Sotozono; Influence of anterior curvature of the lens on Japanese primary angle-closure/glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2084. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Various factors, including lens position and shape, jointly involve primary angle closure/glaucoma (PAC/G). Lens vault (LV) is one of the indicators to quantify the lens position, and we had reported a new indicator, lens protrusion distance (LPD), which quantifies the curvature of anterior lens surface. The purpose of this study was to evaluate the influence of LPD on PAC/G pathophysiology.
This study involved 88 normal Japanese subjects (22 males/66 females; mean age 66.6±5.6 years) and 25 PAC/G patients (6 males/19 females; 66.6±8.8). Inclusion criteria were those who 1) visited the outpatient clinic of Kyoto Prefectural University of Medicine, Kyoto, Japan between June 2014 and April 2016, 2) were diagnosed by glaucoma specialists as normal or PAC/G based on several ophthalmic examinations, and 3) in whom reliable horizontal images could be obtained using anterior segment optical coherence tomography (AS-OCT) (CASIA SS-1000; Tomey, Nagoya, Japan). In all eyes, AS-OCT images were imported to image processing software (Image J 1.48q; NIH). The line connecting the scleral spur (SS) was regarded as the SS-line, and anterior chamber depth (ACD), width (ACW), and LV were defined as described (Nongpiur ME et al., Ophthalmology 2011). LPD were defined as previously reported (Mori K et al., ARVO 2016). In brief, the averaged perpendicular distance at the point of nasally and temporally 2mm apart from visual axis, from the anterior lens surface to the horizontal line at the anterior pole parallel to the SS-line were defined as LPD. The clinical features of age, gender, and axial length (AL) were also obtained. Stepwise multiple regression analysis was performed, regarding LPD as a descriptive value, and age, gender, AL, ACD, LV, and ACW as explanatory variables. Multiple logistic regression analysis with forward selection method was also performed between the normal and PAC/G.
LV and LPD of normal vs. PAC/G subjects were showed in Table 1. Stepwise multiple regression analysis showed that AL was the statistically significant determinant of LPD (p=0.001) in PAC/G patients. Multiple logistic analysis showed that ACD (p<0.001) and LPD (p=0.03) were significant explanatory variables for PAC/G.
Anterior curvature of the lens and anterior chamber depth were significantly related to the PAC/G pathophysiology.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
Table 1. LV and LPD of normal and PAC/G subjects
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