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ying chi, chunying guo, Liu Yang; Peripheral retinal and choroidal changes in anterior uveitis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2165.
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Clinical examinations and conventional fluorescein angiography may not provide enough details for patients with anterior uveitis. We performed a retrospective, observational clinical study to learn about the peripheral retinal and choroidal changes in anterior uveitis using ultra-wide-field angiography(UWFA) and EDI-OCT.
We analyzed one year retrospective data at an academic medical center in china. A total of 83 eyes of 83 patients (right eye) corresponded with the research criteria of anterior uveitis through clinical examination and conventional fluorescein angiography (30−55°) were included. UWFA and EDI-OCT were also obtained in each patient at the same visit.Eyes with peripheral retinal changes displayed UWFA and EDI-OCT at 1 month later and 1 year later.The key observed indexes were score of peripheral vessel leakage(PVL), retinal vessel diameter(RVD) and choroidal thickness(CT). Eyes which were given different kind of treatment were analyzed to suggest which one is the best for improving these indexes and reducing the recurrence frequency.
PVL was detected in 50 eyes by UWFA(64%). The score of PVL was significantly higher in eyes displayed active anterior inflammation than which was inactive(P<0.05). Large vessel layer of the choroid were dilated remarkably in eyes with PVL. Mean CT was significantly more in eyes with PVL(357.1±96.7um) compared to which without PVL(308.9±68.1um); but were not significantly between eyes with and without active anterior inflammation. RVD(Parr-Hubbard method) did not differ between eyes with and without PVL(Artery:138.3±19.4 vs 138.1±22.9;Vein:196.4±18.6 vs 176.1±25.0). CT and score of PVL were significantly decreased 1 month later in eyes which were given Oral prednisone or retrobulbar injection of triamcinolone acetonide(TA)(P<0.05). The recurrence frequency was significant reduced in patients who were given oral prednisone for at least 1 month from the first visit(p<0.05).
There were changes at the peripheral retina and the choroid in anterior uveitis. PVL was found in eyes with anterior uveitis, no matter with or without active anterior inflammation. CT thickening was displayed in eyes with PVL. Oral prednisone and retrobulbar injection of TA were good for PVL and CT. And oral prednisone may be associated with reduced risk of recurrence.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
PVL change of one eye(A.previously;B.first visit;C.1 month;D.1 year)
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