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Ping Situ, Trefford L Simpson, Carolyn G Begley, Nancy J Keir; Diurnal variation of sensory and tearing responses and symptoms in symptomatic and asymptomatic contact lens wearers. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3049. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To examine diurnal variation in corneal sensory processing, tearing response and symptoms in symptomatic and asymptomatic contact lens (CL) wearers.
51 adapted CL wearers and15 normal non-lens wearer controls participated. CL wearers were subdivided into symptomatic and asymptomatic groups based on comfortable wearing time and Contact Lens Dry Eye Questionnaire-8 score. Detection threshold to cool stimulus was estimated using a Belmonte esthesiometer at baseline (BL) before 9 am and within 1 hour of awakening. Following BL measurement, subjects of the contact lens group wore their contact lenses for approximately 8 hours and threshold was estimated again. For the non-lens wear controls, measurements were repeated at 8 hours after BL. Lower tear meniscus height (TMH) was measured using an OCT prior to threshold measurement and immediately following stimulus detection, and symptoms were assessed using the Current Symptom Questionnaire (CSQ) at BL and 8 hours.
Thresholds did not change during the day in controls and asymptomatic contact lens wearers, but the symptomatic group’s threshold decreased by the end of the day (p<0.001). There was no effect of time-of-day on the tearing response, with TMH being similar at the beginning and end of day (p=0.547). On the other hand, symptoms were greater in the symptomatic group at the end of the day, but not in the asymptomatic and control groups (p=0.004).
These data show that ocular surface changes are generally not occurring during the day illustrated by there being no differences in tearing response in the morning and in the afternoon, but in the symptomatic group, their eyes were more uncomfortable after a day of lens wear. This, therefore, appears to point to “higher” processes being partly responsible for the diurnal symptom change in this group.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
Average CSQ scores and TMH at the beginning (BL) and end of day (8h) in symptomatic and asymptomatic contact lens wearers and controls
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