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Won June Lee, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park; Comparison of Prelaminar Tissue Thickness and Anterior Prelaminar Depth in between Glaucoma Patients with and without Laminar Dot Sign. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4018.
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© ARVO (1962-2015); The Authors (2016-present)
To analyze and compare the deep optic nerve head (ONH) structure between the glaucomatous eyes with laminar dot sign (LDS) and without LDS, using the swept-source optical coherence tomography (SS-OCT).
In 45 patients (45 eyes) with early glaucoma, the eyes were classified into LDS and non-LDS groups with the stereoscopic optic disc photography. The deep structure of ONH including the anterior prelaminar depth (APLD), prelaminar tissue thickness (PTT), and lamina cribrosa thickness (LCT) were measured using built-in software of SS-OCT and compared the parameters between LDS and non-LDS groups. Multivariate logistic regression analysis was used to analyze factors associated with LDS presence.
The APLDs of the LDS group were significantly deeper than those of the non-LDS group (LDS vs non-LDS: 407.1 ± 118.7 vs. 324.4 ± 139.5 µm, p=0.038). The PTTs of the LDS group were significantly thinner than those of the non-LDS group (LDS vs non-LDS: 71.4 ± 23.6 vs. 120.7 ± 27.7µm, p<0.001). The thin PTT was significantly associated with the LDS presence (aOR = 0.93, 95% confidence interval: 0.88-0.97, p=0.001).
The SS-OCT showed the significantly deeper APLD and thinner PTT in LDS group compared to those in non-LDS group. The presence of LDS in glaucoma patients can provide valuable information related to the deep structure of the ONH.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
Representative case without lamina dot sign. Disc photography (A) and row SS-OCT image (B) was shown, and measurement was performed in images (C). Yellow dot lines indicated the anterior and posterior border of the lamina cribrosa.
Representative case with lamina dot sign. Disc photography (A) and row SS-OCT image (B) was shown, and measurement was performed in images (C). Yellow dot lines indicated the anterior and posterior border of the lamina cribrosa.
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