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Amelie Pielen, Philipp Glusa, Carsten Framme, Robert Kromer; Heidelberg Engineering Optical Coherence Tomography Angiography Analysis of Macular Flow Density in Primary Open-Angle Glaucoma and Healthy Patients. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1649.
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© ARVO (1962-2015); The Authors (2016-present)
The purpose of this study was to investigate the macular flow density as assessed by optical coherence tomography angiography (OCTA) in eyes with primary open-angle glaucoma (POAG) and age-matched healthy control eyes.
The macular flow density was evaluated using the OCTA (Heidelberg Engineering Spectralis 2 OCT-A) centered on the macula in 30 perimetric POAG eyes (age 73.3±5.5 years) and 30 age-matched healthy control eyes. A custom image analysis approach measured the pixel density after binarization in 5 sectors defined by the ETDRS study (central sector: 1mm diameter, 4 sectors: 3.5mm diameter; for comparison see attached OCTA image with ETDRS sectors). For statistical analysis, one eye was chosen randomly and compared to the healthy control eye using parametric paired t-test.
The macular flow density was significantly altered in the central (p=0.0167), inferior (p=0.0258) and nasal (p=0.0438) sector, while the superior and temporal sector showed no significant difference.
We found a decreased macular microvasculature of the retina determined by Heidelberg Engineering OCTA in POAG patients. These findings suggest that the perfusion is altered in POAG. However, it remains unclear whether this decrease in perfusion is causal to the retinal nerve fiber layer degeneration or secondary to its loss.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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