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Antonio Longo, Caterina Gagliano, Andrea Russo, Roberta Amato, Teresio Avitabile, Roberto Fazio, Giulia Malaguarnera, Salvatore Ficili, Carlo Rapisarda, Michele Reibaldi; RETINAL MORPHOLOGY AND FUNCTION IN PATIENTS WITH DIABETES TYPE 1 WITHOUT RETINOPATHY. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2036.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the retinal morphology and function in pediatric patients with diabetes type 1 without retinopathy.
In a prospective case control study, were included pediatric patients (age < 18 years) with type 1 diabetes and without retinopathy (group D). All patients had normal visual acuity (20/20), and refraction <±2 D. Patients with uncontrolled diabetes, any other ocular, neurologic or systemic pathology, or with previous ocular surgery, were excluded.A group of healthy subjects, matched by age, sex, and refraction was used as control (group C).Patients received an OCT examination and a multifocal ERG recording. OCT was performed in mydriasis, by Spectralis Spectral Domain OCT (Heidelberg engineering, Germany), using a raster scan with 25 horizontal lines (20x20 degrees). In 9 EDTRS areas of the macula, the thickness of the whole retina and of some retinal layers (Outer plexiform, Outer nuclear, Outer retinal) was calculated by Heidelberg Explorer software.Multifocal electroretinogram (61 black and white exagons) was assessed in mydriasys by Retimax Plus (CSO, Scandicci, Italy). Test was performed monocularly according to ISCEV standards; corneal HK loops electrodes were used. P1 amplitude (μV) and P1 latency (ms) in the central area and in four concentric rings were calculated by Retimax software.
Twenty-five diabetic patients (13 m, 12 f; age 11-15 yrs, mean 13±2; age at diabetes onset 1-10 yrs, mean 7±3; mean HbA1c (%) 7.4 ± 0.7)and 25 healthy controls were included in the study.In central area, mean retinal thickness was 278±19 μ in D group and 279±13 μ in controls (p=ns); no difference was seen between two groups in mean thickness of the whole retina and of the retinal layers in all sectors.In central area, P1 amplitude was 1.56±0.48 μV in D group and and 1.58±0.44 μV in Controls (p=ns); in D group reduced amplitude was found in peripheral rings [ring 1 (D:0.52±0.18 μV vs C:0.67±0.19 μV, p=0.010), in ring 2 (D:0.25±0.11 μV vs C:0.36±0.14 μV, p=0.003)]. No correlation was found between P1 amplitude and retinal and layers thickness. No difference was seen in latency in all rings
These data suggest that diabetic patients without retinopathy can have a disfunction of retinal cells in macular area
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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