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Jonathan Maxwell Lam, Lisa A Hark, Jonathan S Myers, L Jay Katz, Safa Siraj, Michael Waisbourd, Priyanka Gogte, Qi J Cui; Validation and Reproducibility of the Heidelberg Edge Perimeter in the Detection of Visual Field Defects in Glaucoma Participants. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2871. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To compare standard automated perimetry (SAP) using Heidelberg Edge Perimeter (HEP) with the Octopus Visual Field (OVF) analyzer and determine test-retest repeatability in detecting glaucomatous visual field losses.
This prospective, cross-sectional study was conducted at Wills Eye Hospital, Philadelphia, PA. Glaucoma participants and healthy controls underwent visual field testing using HEP and OVF. Participants returned for repeat testing to determine test-retest repeatability. The HEP SAP III 30-2 ASTA FAST protocol and OVF G-TOP white-on-white strategy were used. Testing order (HEP/OVF) was randomized. Correlations for both mean deviation (MD) and pattern standard deviation/Loss of Variance (PSD/sLV) were compared. Receiver Operating Characteristic (ROC) analysis was performed to determine the diagnostic ability of HEP and OVF. Intraclass correlation coefficients (ICCs) were calculated to assess test-retest repeatability.
A total of 79 participants with glaucoma and 36 normal controls were enrolled. In the glaucoma group, HEP and OVF were significantly correlated for both MD (r=-0.86; P<0.001) and PSD/sLV (r=0.83; P<0.001). The MD ROC curves were also comparable for OVF (AUC=0.79) and HEP (AUC=0.74; P=0.26). The PSD/sLV ROC curves were similar for the OVF (AUC=0.82) and the HEP (AUC=0.74; P=0.08). The ICCs for test-retest repeatability were higher for HEP (0.96 for MD; 0.95 for PSD) than OVF (0.82 for MD; 0.88 for sLV). The OVF mean test duration was significantly shorter (OVF=2.63 minutes; HEP=5.15 minutes, P<0.0001).
The HEP and OVF showed strong correlation for both MD and PSD parameters in participants with glaucoma. The HEP demonstrated better test-retest repeatability, however its average test duration was significantly greater.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
Figure 1. Bland-Altman plots and correlations between the Heidelberg Edge Perimeter and Octopus Visual Field Analyzer for Mean Deviation and Pattern Standard Deviation/Loss of Variance.
Figure 2. Area under the Receiver Operating Characteristic (ROC) curves for the Heidelberg Edge Perimeter (HEP) and the Octopus Visual Field Analyzer (OVF), showing the diagnostic ability of the two devices. Comparisons were made for Mean Deviation and Pattern Standard Deviation/Loss of Variance.
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