June 2017
Volume 58, Issue 8
ARVO Annual Meeting Abstract  |   June 2017
Influence of glycosylated hemoglobin on diabetic retinopathy

Author Affiliations & Notes
  • jie xu
    fundus, Beijing Institute of Ophthalmology, Beijing, China
    Beijing Ophthalmology and Visual Science Key Lab,, Beijing, China
  • wenbin wei
    Beijing Ophthalmology and Visual Science Key Lab,, Beijing, China
  • Jost B Jonas
    Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany
  • Footnotes
    Commercial Relationships   jie xu, None; wenbin wei, None; Jost Jonas, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2892. doi:
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      jie xu, wenbin wei, Jost B Jonas; Influence of glycosylated hemoglobin on diabetic retinopathy

      . Invest. Ophthalmol. Vis. Sci. 2017;58(8):2892.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : We aimed to provide updated data for the relation between Glycosylated hemoglobin( HbA1c) and diabetic retinopathy(DR), and to estimate cut-off of HbA1c for DR.

Methods : A cluster sampling technique was used to identify and include patients with type 2 diabetes mellitus from urban Beijing communities. HbA1c was measured by the liquid chromatography technique.Fundus photographs were graded using the modified Airlie House classification system.

Results :
Of 2,642 eligible patients, 2,007 (76.0%) subjects (1,199 women) with a mean age of 64.1 6 9.0 years participated. The overall prevalence of DR was 24.7 ±1.0% (95% confidence interval [CI], 22.8–26.6). In binary logistic analysis, presence of DR was associated with younger age (odds ratio [OR], 0.97; 95% CI, 0.95–0.98), longer duration of diabetes (OR, 1.10; 95% CI, 1.08–1.12), higher concentration of HbA1c (OR, 1.23; 95% CI, 1.14–1.33), higher systolic blood pressure (OR, 1.01; 95% CI, 1.01–1.02), lower body mass index (OR, 0.95; 95% CI, 0.92–0.98), and elevated blood urea concentration (OR, 1.01; 95% CI, 1.00–1.01). The Receiver Operating Characteristic analysis showed that the cut-off value of 6.5 had 75.1% sensitivity and 43.4% specificity with 59.2% maximum area under the curve.

Conclusions : HbA1c value ≥6.5% was significantly related with DR and PDR. In a screening program, the cut-off value of HbA1c≥6.5% may provided a maximum yield of DR.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.




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