June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Variable Interscan Time Analysis (VISTA-) Optical Coherence Tomography Angiography (OCTA) of Blood Flow Speeds in Eyes with Diabetic Retinopathy
Eric M. Moult; Stefan B. Ploner; Carl B Rebhun; A. Yasin Alibhai; ByungKun Lee; Carlos Moreira; Eduardo Amorim Novais; Julia Schottenhamml; Lennart Husvogt; Andreas K Maier; Philip J Rosenfeld; Jay S Duker; Nadia Waheed; James G Fujimoto
Author Affiliations & Notes
  • Eric M. Moult
    Electrical Engineering and Computer Science, MIT, Cambridge, Massachusetts, United States
    Health Sciences and Technology, Harvard-MIT, Cambridge, Massachusetts, United States
  • Stefan B. Ploner
    Pattern Recognition Lab, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
    Electrical Engineering and Computer Science, MIT, Cambridge, Massachusetts, United States
  • Carl B Rebhun
    New England Eye Center , Tufts Medical Center, Boston, Massachusetts, United States
  • A. Yasin Alibhai
    New England Eye Center , Tufts Medical Center, Boston, Massachusetts, United States
  • ByungKun Lee
    Electrical Engineering and Computer Science, MIT, Cambridge, Massachusetts, United States
  • Carlos Moreira
    New England Eye Center , Tufts Medical Center, Boston, Massachusetts, United States
  • Eduardo Amorim Novais
    New England Eye Center , Tufts Medical Center, Boston, Massachusetts, United States
    School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Julia Schottenhamml
    Electrical Engineering and Computer Science, MIT, Cambridge, Massachusetts, United States
    Pattern Recognition Lab, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
  • Lennart Husvogt
    Electrical Engineering and Computer Science, MIT, Cambridge, Massachusetts, United States
    Pattern Recognition Lab, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
  • Andreas K Maier
    Pattern Recognition Lab, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
  • Philip J Rosenfeld
    Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Jay S Duker
    New England Eye Center , Tufts Medical Center, Boston, Massachusetts, United States
  • Nadia Waheed
    New England Eye Center , Tufts Medical Center, Boston, Massachusetts, United States
  • James G Fujimoto
    Electrical Engineering and Computer Science, MIT, Cambridge, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Eric Moult, None; Stefan Ploner, None; Carl Rebhun, None; A. Yasin Alibhai, None; ByungKun Lee, None; Carlos Moreira, None; Eduardo Novais, None; Julia Schottenhamml, None; Lennart Husvogt, None; Andreas Maier, None; Philip Rosenfeld, Carl Zeiss Meditec, Inc. (F), Carl Zeiss Meditec, Inc. (C); Jay Duker, Carl Zeiss Meditec, Inc. (F), Carl Zeiss Meditec, Inc. (C), Optovue, Inc. (F), Optovue, Inc. (C), Topcon Medical Systems, Inc. (F), Topcon Medical Systems, Inc. (C); Nadia Waheed, Carl Zeiss Meditec, Inc. (R), Genentech (C), Janssen (C), MVRF (F), Nidek (R), Ocudyne (C), Optovue, Inc. (R), Regeneron (C); James Fujimoto, Carl Zeiss Meditec, Inc. (P), Optovue, Inc. (I), Optovue, Inc. (P)
  • Footnotes
    Support  NIH 5-R01-EY011289-28, AFOSR FA9550-15-1-0473, AFOSR FA9550-10-1-0551, MVRF
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 84. doi:
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      Eric M. Moult, Stefan B. Ploner, Carl B Rebhun, A. Yasin Alibhai, ByungKun Lee, Carlos Moreira, Eduardo Amorim Novais, Julia Schottenhamml, Lennart Husvogt, Andreas K Maier, Philip J Rosenfeld, Jay S Duker, Nadia Waheed, James G Fujimoto; Variable Interscan Time Analysis (VISTA-) Optical Coherence Tomography Angiography (OCTA) of Blood Flow Speeds in Eyes with Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2017;58(8):84.

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Abstract

Purpose : The introduction of optical coherence tomography angiography (OCTA) allows clinicians to study the microvascular alterations that occur in diabetic retinopathy (DR). Standard OCTA systems yield a detailed picture of the presence of vasculature, but have limited dynamic range and provide little information about blood flow speeds. Our group has recently developed variable interscan time analysis (VISTA), which provides a framework for studying relative blood flow speeds using OCTA. This study investigates VISTA to assess microvascular blood flow speeds in eyes with DR.

Methods : Using a VISTA protocol we analyzed 3 eyes with mild non-proliferative DR (NPDR) (2 patients; 66.7±2.31 y/o), 5 eyes with moderate NPDR (3 patients; 57.6±16.58 y/o), 5 eyes with severe NPDR (4 patients; 51.8±13.44 y/o), and 8 eyes with proliferative DR (PDR) (6 patients; 57.0±13.38 y/o).

Results : We observed a range of flow distributions associated with capillary looping/microaneurysms, tortuous vessels, dilated vessels, and neovasculature vessels. Representative VISTA-OCTA images are shown in Figures 1 and 2.

Conclusions : VISTA is a useful framework for studying blood flow speeds in eyes with DR.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

(A) 68 y/o mild NPDR eye (6x6mm field). (B) 28 y/o moderate NPDR eye (3x3mm field). (A-B).1 Color fundus photos. (A-B).2 Fluorescein angiography. (A-B).3 En face OCTA projections through the retinal vasculature. (A-B).4 VISTA-OCTA images. (A-B.3.1) Enlargements of white boxes in A-B.3. (A-B.4.1) Enlargements of white boxes in A-B.4. White arrows point to suspected capillary loops and/or microaneurysm-like features. In VISTA-OCTA images, blue vs red correspond to slower vs faster blood flow, respectively.
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(A) 68 y/o mild NPDR eye (6x6mm field). (B) 28 y/o moderate NPDR eye (3x3mm field). (A-B).1 Color fundus photos. (A-B).2 Fluorescein angiography. (A-B).3 En face OCTA projections through the retinal vasculature. (A-B).4 VISTA-OCTA images. (A-B.3.1) Enlargements of white boxes in A-B.3. (A-B.4.1) Enlargements of white boxes in A-B.4. White arrows point to suspected capillary loops and/or microaneurysm-like features. In VISTA-OCTA images, blue vs red correspond to slower vs faster blood flow, respectively.

(A) 68 y/o mild NPDR eye (6x6mm field). (B) 28 y/o moderate NPDR eye (3x3mm field). (A-B).1 Color fundus photos. (A-B).2 Fluorescein angiography. (A-B).3 En face OCTA projections through the retinal vasculature. (A-B).4 VISTA-OCTA images. (A-B.3.1) Enlargements of white boxes in A-B.3. (A-B.4.1) Enlargements of white boxes in A-B.4. White arrows point to suspected capillary loops and/or microaneurysm-like features. In VISTA-OCTA images, blue vs red correspond to slower vs faster blood flow, respectively.

(A) 68 y/o mild NPDR eye (6x6mm field). (B) 28 y/o moderate NPDR eye (3x3mm field). (A-B).1 Color fundus photos. (A-B).2 Fluorescein angiography. (A-B).3 En face OCTA projections through the retinal vasculature. (A-B).4 VISTA-OCTA images. (A-B.3.1) Enlargements of white boxes in A-B.3. (A-B.4.1) Enlargements of white boxes in A-B.4. White arrows point to suspected capillary loops and/or microaneurysm-like features. In VISTA-OCTA images, blue vs red correspond to slower vs faster blood flow, respectively.
View OriginalDownload Slide
 
(A) 56 y/o severe NPDR eye (3x3mm field). (B) 65 y/o PDR eye (3x3mm field). (A-B).1 Color fundus photos. (A-B).2 Fluorescein angiography. (A-B).3 En face OCTA projections through the retinal vasculature. (A-B).4 VISTA-OCTA images. (A-B.3.1) Enlargements of white boxes in A-B.3. (A-B.4.1) Enlargements of white boxes in A-B.4. White arrows point to suspected capillary loops and/or microaneurysm-like features, red arrows point to a tortuous vessel, and orange arrows point to vessel dilation. In VISTA-OCTA images, blue vs red correspond to slower vs faster blood flow, respectively.
View OriginalDownload Slide

(A) 56 y/o severe NPDR eye (3x3mm field). (B) 65 y/o PDR eye (3x3mm field). (A-B).1 Color fundus photos. (A-B).2 Fluorescein angiography. (A-B).3 En face OCTA projections through the retinal vasculature. (A-B).4 VISTA-OCTA images. (A-B.3.1) Enlargements of white boxes in A-B.3. (A-B.4.1) Enlargements of white boxes in A-B.4. White arrows point to suspected capillary loops and/or microaneurysm-like features, red arrows point to a tortuous vessel, and orange arrows point to vessel dilation. In VISTA-OCTA images, blue vs red correspond to slower vs faster blood flow, respectively.

(A) 56 y/o severe NPDR eye (3x3mm field). (B) 65 y/o PDR eye (3x3mm field). (A-B).1 Color fundus photos. (A-B).2 Fluorescein angiography. (A-B).3 En face OCTA projections through the retinal vasculature. (A-B).4 VISTA-OCTA images. (A-B.3.1) Enlargements of white boxes in A-B.3. (A-B.4.1) Enlargements of white boxes in A-B.4. White arrows point to suspected capillary loops and/or microaneurysm-like features, red arrows point to a tortuous vessel, and orange arrows point to vessel dilation. In VISTA-OCTA images, blue vs red correspond to slower vs faster blood flow, respectively.

(A) 56 y/o severe NPDR eye (3x3mm field). (B) 65 y/o PDR eye (3x3mm field). (A-B).1 Color fundus photos. (A-B).2 Fluorescein angiography. (A-B).3 En face OCTA projections through the retinal vasculature. (A-B).4 VISTA-OCTA images. (A-B.3.1) Enlargements of white boxes in A-B.3. (A-B.4.1) Enlargements of white boxes in A-B.4. White arrows point to suspected capillary loops and/or microaneurysm-like features, red arrows point to a tortuous vessel, and orange arrows point to vessel dilation. In VISTA-OCTA images, blue vs red correspond to slower vs faster blood flow, respectively.
View OriginalDownload Slide

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