Abstract
Purpose :
To evaluate the accuracy of automatically produced corneal thickness maps from iVue and Avanti SD-OCT corneal B-scans (Optovue, Inc., Fremont, CA) and their agreement with manual B-scan corneal thickness measurements in normal eyes and eyes with corneal pathologies.
Methods :
A total of 88 eyes from 88 subjects (17 Normal, 16 contact-lens, 19 dry-eye, 20 post-laser refractive surgery, and 16 keratoconus) were enrolled in IRB approved studies across three study sites. Four eyes’ data were excluded from analysis due to insufficient OCT scan quality: one from iVue and three from Avanti data sets. Manual grading was performed on the 87 qualified iVue and 85 Avanti scans. Corneal pachymetry scans from the same eye were acquired on iVue and Avanti (Fig.1A and 1B) systems. Thickness maps including corneal pachymetry, epithelial, and stroma measurements were automatically generated in the central 6 mm and 9 mm diameter regions of the cornea on iVue and Avanti, accordingly. The accuracy of the software-generated thickness maps computed from the automatic segmented boundaries (Fig. 1C) was assessed by the agreement with averaged manual measurements (Fig. 1D) from three independent human graders for 17 and 25 zonal thickness parameters on iVue and Avanti, respectively (Fig. 2A and 2B).
Results :
For all map zones on both systems, the mean of differences between the automatic and manual measurements was less than 0.7 and 1.4 μm for corneal epithelial mapping, less than 1.9 and 5.9 μm for corneal stroma mapping, and less than 2.3 and 4.7 μm for pachymetry mapping on iVue and Avanti systems respectively (Fig. 2, Tables 1 and 2).
Conclusions :
This study demonstrated the automatically generated corneal maps by iVue and Avanti are accurate, as shown by good agreement with manual measurements.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.