Abstract
Purpose :
Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) enable in vivo imaging of ophthalmic structures. Multimodality SLO-OCT systems provide complementary en face and cross-sectional information for aiming, bulk motion registration, and multi-field mosaicking. We previously demonstrated a swept-source spectrally-encoded SLO and OCT (SS-SESLO-OCT) system using single-mode illumination and multimode collection through a double-clad fiber coupler to improve collection efficiency and reduce speckle contrast. Here, we present a novel SS-SESLO-OCT system for wide-field imaging at 400 kHz line-rate.
Methods :
SESLO and OCT illumination and optical triggering and clocking used a shared 1060 nm Axsun swept-source optically buffered to 400 kHz. SESLO and OCT images were acquired simultaneously on a dual-channel digitizer with a combined throughput of 2.4 GS/s using shared imaging optics and digitization, triggering, and clocking electronics (Fig. 1(a), (b)).
Results :
In vivo ophthalmic imaging was performed in a healthy volunteer under an IRB-approved protocol. Corneal (Fig. 1(c)-(e)) and widefield retinal (Fig. 1(f)-(h)) images were sampled at 2560 x 2000 pix. (spectral x lateral) with 1400 frames-per-volume at 200 frames-per-second. A full en face SESLO frame was acquired simultaneously with each OCT cross-section. Multimode collection provided >3x increase in collection efficiency and >3.5x reduction in speckle contrast.
Conclusions :
SS-SESLO-OCT enables high-speed multimodal widefield imaging of ocular structures. Simultaneous en face and cross-sectional imaging provides complementary information that may be used for image aiming, retinal tracking, and multi-volumetric registration, averaging, and mosaicking.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.