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ruan jiali, Cheng Chen, Shaohong Qian; Construction of a 2-D Photonic Crystal Glucose Sensor for Sensing Glucose in Tears. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3937.
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Noninvasive and real-time glucose monitoring is urgently needed in patients’ glucose control. As a promising material, photonic crystal (PC), shows huge potential for monitoring glucose in tears. However, low sensitivity and response time-lapse block its way into clinical generalization.
We design a novel GMCC material by embedding a 500 nm two-dimensional (2D) polystyrene (PS) colloidal crystal (CC) in 4-aldehydephenylboric acid-modified poly(vinyl alcohol) (PVA) hydrogel to monitor tear glucose in human.Both glucose solution and artificial tears with benching concentrations were detected by an automatic biochemical analyzer, which were also tested by the GMCC sensor, qualitatively with color changing and quantitatively with the diffraction wavelength shifting.
Such sensor could efficiently diffract visible light, whose wavelength could be shifted from 577 nm to 468 nm as glucose concentration altered under physiologically range from 0 mM to 20 mM, covering both tears’ and bloods’, visually seen as color changed from reddish yellow through green to blue at fixed viewing angle of 19. The representative response time was ~200 seconds at the glucose concentration of 10 mM, showing trend as the higher the glucose concentration goes, the faster the GMCC responses. Moreover, the GMCC avoided the interference induced by the complex elements in tears, since it comprised a specific glucose-responding agent.
The changing diffraction of the GMCC can literally reflect the fluctuating concentration of tear glucose with the change of the structure color.With the characteristics of high sensitivity and accuracy in detecting glucose concentration in tears, this intelligent sensing material is both convenient and portable in social life utility, thereby presents great possibility to bring itself into the frontier of glucose analyzing device.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
Fig 1, the 2D PS PC self-assembled with a highly periodic structure of a closely packed hexagonal monolayer structure.
Fig 2, GMCC could diffract visible light, whose wavelength could be shifted from 577 nm to 468 nm as glucose concentration altered under physiologically range from 0 mM to 20 mM.
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