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Jiwoong Lee, Keunheung Park; Reproducibility of Bruch’s membrane opening-minimum rim width measurements with Spectralis optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4009.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the reproducibility of Bruch’s membrane opening-minimum rim width (BMO-MRW) measurements and influencing factors.
One hundred twenty-three subjects were recruited for the study: 65 healthy and 58 glaucoma subjects. Spectral-domain optical coherence tomography (SD-OCT, Spectralis, Heidelberg, Germany) was performed to all subjects. BMO-MRW measurements were repeated three times during the same visit. The segmentation was checked by a fellow trained glaucoma specialist and corrected when necessary. Intravisit repeatability, coefficient of variation (CV) and intraclass correlation coefficient (ICC) was calculated.
The intravisit repeatability was from 2.97 (global area) to 10.25 (inferotemporal sector) in healthy subjects and from 3.31 (global area) to 12.09 (inferonasal sector) in glaucoma subjects. The CVs ranged from 1.17% (global area) to 3.56% (inferotemporal sector) in healthy subjects and from 2.57% (global area) to 6.46% (superotemporal sector) in glaucoma subjects. ICCs ranged from 0.974 (superotemporal sector) to 0.997 (nasal sector) in normal subjects and from 0.988 (temporal sector) to 0.997 (global area and nasal sector) in glaucoma subjects. Multiple regression analysis showed that the CV in global BMO-MRW measurements was negatively correlated with global BMO-MRW and visual field mean deviation (P = 0.003, P = 0.005, respectively).
The spectralis SD-OCT showed excellent reproducibility of BMO-MRW measurements in both normal and glaucoma subjects. The measurements variability increased as the glaucoma progresses.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
Figure 1. Scatter plot of CV versus global BMO-MRW. Healthy subject marked as (H) and glaucoma subject marked as (G).
Figure 2. Scatter plot of CV versus visual field MD. Healthy subject marked as (H) and glaucoma subject marked as (G).
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