In vivo measurement of hemodynamic parameters and its association factors in Chinese healthy subjects

Abstract

Purpose : To measure hemodynamic parameters in Chinese healthy subjects by using phase resolved Doppler OCT (PR-D-OCT).

Methods : Healthy adult Chinese subjects were recruited. All subjects underwent ophthalmic examinations, including subjective refraction, anterior and posterior segment examination, IOL-Master, non-contact tonometer and D-OCT imaging, using the raster scan and circular scan. Four retinal branch arteries in four orientation（superior and inferior in both temporally and nasally） were chosen. Resistance index (RI) and pulsatility index (PI) were calculated by using custom developed semi-automated analysis software. Mean of nasal hemodynamic index indicates the nasal hemodynamic change, as well as temporal. The relationship between the hemodynamic parameters and its association factors was investigated.

Results : A total of 96 eyes in 48 subjects were included(30 males and 20 females, mean age 35±14y) . The mean axial length was 23.62 ± 1.19 mm, the mean IOP was 13.54 ± 2.1 mmHg, the mean SE was -1.50 ± 2.4D. In normal subjects, the mean RI was 0.74±0.06, the mean PI was 1.19±0.16. This study shows the relationship between hemodynamic parameters and age, including RI (R=-0.59, P<0.01), PI (R=-0.58, P<0.01). Hemodynamic parameters were not significantly correlated with other association factors, including axial length, IOP, SE.

Conclusions : Hemodynamic parameters decreased with age, indicating the perfusion of fundus weakened with age.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Fig1:Pulsatile flow of retinal vessel indicated as blue lines. peak systolic velocity (S); middle, average velocity (A), bottom, end
diastolic velocity (D).Resistance index is defined as(S-D)/S, pulsatility index is defined as (S-D)/A

 

Fig2:Hemodynamic parameters and its association factors