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Muhammad Hassan, Adithi Chakarvarthy, Mahadevan Subramaniam, Parvathi Chundi, Muhammad Fayez Jawed, Muhammad Sohail Halim, Mohammad Ali Sadiq, Rubbia Afridi, Yasir Jamal Jamal Sepah, Quan Dong Nguyen, Diana V Do, Eyal Margalit; Correction of Perceived Visual Distortions Using a Software Application and Correlation to Age-Related Macular Degeneration.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5631.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the effect of customized software-generated corrections in cancelling the perceived distortions in subjects with age-related macular degeneration (AMD).
An android tablet-based application displaying 3 lines (Fig. 1A) was utilized to elicit distortions. Five subjects (7 eyes: neovascular-AMD and 3 eyes: non-neovascular AMD) were asked to trace reference lines (RL) (Black line, Fig. 1A) and their distortion traces (DT) were recorded (green line, Fig. 1B). To counter the distortion, a compensatory software-generated trace (GT) was produced (purple line, Fig. 1B). The RL were recalibrated to GT and subject was asked to re-trace the lines. The corrected trace (CT) was recorded (yellow line, Fig. 1C) and compared to RL. Tablet recording was superimposed onto the en-face image of spectral domain optical coherence tomography (SD-OCT) (Fig. 1D). The number of distorted lines associated with an underlying lesion on SD-OCT was reported by two independent graders. To measure the effectiveness of correction, best fit lines were generated through the DT, GT and CT (Fig. 1E). The distortion and correction was measured by calculating the distance of DT(dDT) and CT(dCT) form the RL (Fig. 1F). Mean percentage improvement in the distortion was reported. Effectiveness of correction (EoC) was reported by utilizing t-test to compare the mean distance of DT and CT from RL (Fig. 1F).
Mean age was 76.6 (±9.5) yrs. Each subject traced 6 RLs (3 Lines/eye). Each RL was treated as a separate case. We analyzed 30 cases: 17 (56.6%) cases elicited distortion while 13 cases without distortion were not analyzed further. Mean percentage improvement in distortion was 71.3±23.0%. There was a significant improvement in mean dCT compared to dGT (EoC; p<0.05). 12 cases (70.6%) had an AMD lesion associated with distortion; 8 cases with lesion had photoreceptor layer (PRL) disruption, while 4 had normal PRL. Mean EoC in cases with normal PRL was significantly higher than with abnormal PRL(P<0.05). 5 cases with distortion had no associated underlying lesion. Mean improvement in these subjects was significantly more than those with PRL disruption (p<0.05) and similar to those with normal PRL (p>0.05).
Software generated corrections can potentially correct for perceived distortions in subjects with AMD, especially in eyes with preserved photoreceptor layer.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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