Purchase this article with an account.
Vladimir Yevseyenkov, Elizabeth Murray, Lisa Holtman, Jason Merrell; Ganglion Cell Complex Optical Coherence Tomography Analysis in Glaucoma Patients: Spectralis vs. RTVue. Invest. Ophthalmol. Vis. Sci. 2017;58(8):709.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To correlate the ability to assess retinal ganglion cell complex (GCC) thickness measurements by utilizing two different methodologies of measuring ganglion cell complex which has been identified as a key player in early glaucoma detection. We will utilize Spectralis OCT posterior pole analysis which measures the whole retinal thickness vs RTVue GCC analysis that actually separates the GCC.
16 subjects with a determined history of various stages of glaucoma were scanned as part of their regular eye exam utilizing two different optical coherence tomographers (Spectralis OCT posterior pole analysis and RTVue OCT GCC analysis). At 6 months, the subjects were scanned at a follow up and the level of progression was noted. There were 3 data points analyzed: superior, inferior and total thickness around the area of the macula. The level of progression, thickness consistancy measurements, correlation of thickness measuremets between the two instruments was compared. All data was analyzed utilizing Excel correlation coefficient.
Intra class correlation coefficient (r) comparing the two devices for all three measurements (superior, inferior and total thickness) showed very consistent results and ranged from 0.87 to 0.92 with all measurements having a p<.001. 95% limits of agreement (LoA) showed very little variation among normal adults for these measurements indicating good test retest reliability of the devices. Results indicate very little variation among normal adults, and showed non signficant progression of retinal thinning in the span of 6 month for both devices.
There is a significant positive relationship between measuring the whole retinal thickness at the macula by both the posterior pole analysis on the Spectralis OCT and the ganglion cell complex analysis that separates GCC layers that is done by RTVue OCT. Therefore, it is our conclusion that separating specific layers vs measuring full retinal thickness are a very similar method for measuring progression of glaucoma utilizing ganglion cell layer analysis.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
This PDF is available to Subscribers Only