Abstract
Purpose :
To study the association between intraocular pressure (IOP), and diameter of retinal vessels (central retinal arteriolar equivalent and central retinal venular equivalent [CRVE]) with maximum cup depth (MCD) in subjects with and without primary open angle glaucoma (POAG) in the population-based study.
Methods :
All individuals who participated in the population-based Handan Eye Study (HES) who had gradable fundus photographs and Hiedelberg Retinal tomography (HRT 2) images were eligible for inclusion. The association of maximum cup depth (MCD) with IOP, central retinal arteriolar equivalent (CRAE）and central retinal venular equivalent （CRVE）as measured on fundus photographs) while adjusting for other confounders was determined.
Results :
Data from forty subjects with and 4194 non-glaucoma without POAG from the HES who fulfilled the inclusion and exclusion criteria were analyzed. On univariable analysis, MCD was significantly associated with younger age, male gender, lower mean systolic blood pressure, lower refractive error, higher IOP, longer axial length, narrower CRAE, narrower CRVE, larger disc area, and with lower prevalence of hypertension, and diabetes. On multivariable analysis the significant independent determinants of MCD were larger disc area (DA)( P<0.001; standardized beta coefficient: 0.43; correlation coefficient B: 0.21; 95%CI: 0.20 - 0.23), younger age (P<0.001; beta: -0.10; B: -0.002; 95%CI: -0.003 - 0.001), male gender (P<0.001; beta: -0.08; B: -0.03; 95%CI: -0.05 - 0.02), higher IOP (P=0.02; beta: 0.04; B: 0.003; 95%CI: 0.000 - 0.005), diagnosis of POAG (P<0.001; beta: 0. 0.08; B=0.17; 95%CI: 0.100 - 0.236), narrower CRAE (P<0.001; beta: -0.06; B=-0.001; 95%CI: -0.001, - <0.001). The association between narrow CRAE and deeper maximum cup depth was stronger than for other optic disc parameters (P≥0.210).
Conclusions :
An increased MCD was significantly associated with higher IOP and narrower CRAE while ajusted for other confounders in the Chinese adult population. As MCD is a marker of glaucomatous optic nerve damage (ONH), our findings lend support to the role of both intraocular pressure factor as well as vascular factors in the pathogenesis of ONH damage in POAG.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.