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Alice Chandra Verticchio Vercellin, Alon Harris, Brent A Siesky, Nathaniel Kim, Tyler Knight, Adrienne Ng, George Eckert, Yara Catoira-Boyle, Josh C Gross; Baseline macular thickness correlates more strongly with changes in retinal capillary blood flow in open angle glaucoma patients with diabetes mellitus after 4 years. Invest. Ophthalmol. Vis. Sci. 2017;58(8):741. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the relationship between baseline macular thickness and changes in retinal capillary blood flow in open angle glaucoma (OAG) patients with and without diabetes mellitus (DM) over 4 years.
82 patients with OAG (16 with DM, 66 without DM) were evaluated for baseline macular thickness by optical coherence tomography and retinal capillary blood flow by Heidelberg retinal flowmetry (HRF) every 6 months for 4 years. Pearson correlations were used to test for associations between measurements with p<0.05 considered statistically significant.
In OAG patients with DM, baseline outer nasal macular thickness (r=-0.64, p<0.01), inner nasal macular thickness (r=-0.77, p<0.00), outer temporal macular thickness (r=-0.53, p<0.04), and inner temporal macular thickness (r=-0.77, p<0.00) were negatively and significantly correlated with changes in the percentage of avascular area in the superior retina. In non-DM patients, these relationships were weakly correlated and significantly different compared to OAG patients with DM (all comparisons p<0.05). The percentage of avascular area in the inferior retina did not differ significantly between groups.
In OAG patients with DM, lower baseline macular thickness was associated with decreasing retinal capillary blood flow after 4 years.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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