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Janis B. Orr, Madara Zvirgzdina, James Wolffsohn; The influence of age, ethnicity, eye/body size and diet on corneal biomechanics.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1131. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Orthokeratology (ortho-k) is a convenient, effective method of refractive error correction, and has been shown to play an important role in myopia control. However, there is substantial inter-patient variation in treatment response, which has been attributed to corneal biomechanical factors. Evaluation of the influence of age, ethnicity, eye size (axial length), body size (height/weight) and diet on corneal biomechanics may allow prediction of treatment outcome and aid patient selection.
One hundred and fifty-eight healthy volunteers were recruited (mean±SD age: 32.4±12.3 years, range 19 to 63 years; mean±SD; mean spherical equivalent, MSE: -1.46±2.25 D, range -11.81 to 3.60 D). Axial length was measured using and an optical biometer (IOL Master 500). Height and weight measurements were taken using a stadiometer and a mechanical scale. Food consumption data were recorded, using an adapted 90 item Food Frequency Questionnaire (FFQ). Corneal biomechanics were measured using the Ocular Response Analyser.
Corneal hysteresis (CH) and corneal resistance factor (CRF) were not influenced by age (CH: p=0.586; CRF: p=0.173), ethnicity (CH: p=0.586; CRF: p=0.493), diet (CH: p=0.681; CRF: p=0.952), height/weight (CH: p=0.35; CRF: p=0.394) or axial length (CH: p=0.256; CRF: p=0.866). However, other ORA derived metrics were significantly influenced by axial length, height/weight, and higher meat intake (all p<0.005).
Whereas ethnicity and age have no influence corneal biomechanics, axial length, height/weight and higher meat intake do influence a number of ORA-derived corneal biomechanical metrics; but not CH or CRF. Variations in the additional ORA-derived parameters reflect the complex nature of corneal biomechanical response, and suggest that they should be considered alongside CH and CRF, when investigating/predicting corneal biomechanical response to orthokeratology.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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