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Yuma Shibahara, Toshikatsu Kaburaki, Rie Tanaka, Mitsuko Takamoto, Hisae Nakahara, Ayako Karakawa, Yujiro Fujino, Makoto Aihara; Evaluation of iris volume in Fuchs' Heterochromic Iridocyclitis using three-dimensional anterior segment optic coherence tomography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1286.
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© ARVO (1962-2015); The Authors (2016-present)
Iris atrophy is one of the important diagnostic findings in Fuchs heterochromic iridocylitis (FHI).However, there has been no reports that quantitative evaluation of iris atrophy by measuring the iris volume. In this study, we evaluated the iris volume of FHI patients using an anterior segment optical coherence tomography (AS-OCT) to determine the iris atrophy of the affected eyes quantitatively.
Twenty-one FHI patients (10 male, 11 female, 49.0±14.6 years old) and seventeen healthy volunteers (7 male, 10 female, 39.4±7.5 years old) were enllored. All FHI patients suffered unilateral chronic uveitis with diffuse iris stroma atrophy with or without heterochromia, and cataract (or history of cataract surgery). We obtained OCT images of the affected eyes and the fellow eyes of FHI patients and both eyes of healthy volunteers in a darkened room (20 lux) and flashing a light into fellow eye (900 lux) using AS-OCT (CASIA SS-1000, Tomey Corporation, Nagoya, Japan) and determined the iris volume. We compared the iris volume of the affected eyes to the fellow eyes and eyes of healthy volunteers.
Iris volume of the affected eyes were 32.70 ± 4.45mm3, compared to those of the fellow eyes (36.60 ± 4.24 mm3), healthy right eyes (38.58 ± 3.66 mm3), healthy left eyes (38.58±3.76mm3). Iris volume of affected eyes was significantly smaller than those of the fellow eyes (P<0.001, paired t-test), healthy right eyes (P<0.001, unpaired t-test), and healthy left eyes (P<0.001, unpaired t-test). On the contrary, there were no significant differences between the fellow eyes and healthy right eyes (P=0.14, unpaired t-test).
Iris volume of the affected eyes of FHI patients was significantly smaller than those of the fellow eyes of FHI patients and healthy volunteers’ eyes. The comparisons of iris volume in the affected eyes and the fellow eyes have a potential to be a diagnostic marker for FHI.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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