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Dalila Gil Alves, Torcato Santos, Inês Marques, Catarina A Neves, Mario Soares, Conceição Lobo, Jose G Cunha-Vaz; Agreement between OCT-Leakage and Fluorescein Angiography to identify sites of alteration of the Blood-Retinal Barrier in Diabetes. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1654. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the location of the sites of lower reflectivity, as determined by OCT-Leakage using Spectral Domain Optical Coherence Tomography (SD-OCT), with sites of fluorescein leakage identified by Fluorescein Angiography (FA) in eyes with diabetic retinopathy.
Fifty-two eyes from 28 patients with diabetes type 2 and presence of non-proliferative diabetic retinopathy were imaged with FA and SD-OCT (AngioPlex, Carl Zeiss Meditec, Inc.). All FA images were analyzed by 2 experienced graders, and the area surrounding well-defined sites of leakage was outlined by the graders. The SD-OCT scans were processed using OCT-Leakage proprietary software and semi-automated segmentation. Both procedures were performed without access to the clinical data.
In eyes that were classified as having well-defined sites of leakage on FA, OCT-Leakage showed a sensitivity of 95.9% (91.4% - 100.0%) and a specificity of 75.4% (61.7% - 89.2%) regarding agreement between these sites of alteration of the Blood-Retinal Barrier (BRB). The areas of abnormal extracellular fluid increase were larger than the areas of fluorescein leakage and included the well-defined leakage sites identified by FA. OCT-Leakage identified localized increases in extracellular space, mainly in the Inner Nuclear, Outer Plexiform or Outer Nuclear Layers, even in eyes without leakage on FA.
OCT-Leakage performed using SD-OCT was found to better identify abnormal retinal fluid than did FA and showed good sensitivity and specificity in comparison with FA for identification of sites of alterations of the BRB.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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