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Daniele De Geronimo, Maria Cristina Parravano, Fabio Scarinci, Lea Querques, Gianni Virgili, Joseph Simonett, Monica Varano, Francesco Bandello, Giuseppe Querques; Relationship between internal reflectivity of diabetic microaneurysms on SD-OCT and detection on OCT Angiography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1662. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To correlate the appearance of microaneurysms (Mas) on structural SD-OCT with their detection on OCT angiography (OCT-A) in patients with non proliferative diabetic retinopathy (NPDR).
Observational cross-sectional clinical study. Sixteen patients with mild, moderate or severe NPDR without diabetic macular edema underwent SD-OCT and OCT-A on the same day. Two observers blinded to patient groupings evaluated reflectivity of MAs on structural SD-OCT scans and their visualization at the level of superficial capillary plexus (SCP) and deep capillary plexus (DCP) on OCT-A.
The study included one hundred and thirty-five MAs detectable on OCT-A; 56.3% (n 76) were visible only in the DCP, 6.7% (n 9) only in the SCP, 21.5% (n 29) were visible in both plexuses (mixed) ; finally 15.6% (n 21) were not visible on any OCT-A images. Compared to MAs with hyper reflectivity or moderate reflectivity, MAs with hypo reflectivity on structural SD-OCT were significantly less likely to be detected on OCT-A (OR: 4.6; 95%CI: 1.5-14.0, p = 0.008; and OR: 4.2, 95%CI 1.2-14.2, p = 0.022, respectively). Compared to non-visible MAs, superficial (OR: 1.7, 95% CI: 0.4 – 8.4), mixed (OR: 2.5; 95% CI: 0.8-7.8) and deep (OR: 3.6; 95% CI: 1.3-9.7) MAs were increasingly more likely to be more reflective (test for trend p=0.011), though only the OR of deep MAs reached significance when position was a categorical variable (p=0.013).
MAs that appear hyporeflective on structural SD-OCT have a lower detection rate on OCTA images. This relationship between the internal reflectivity of MAs on structural SD-OCT and their visualization on the OCT-A images may help further understand the different pattern of blood flow dynamics in MAs.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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