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Giulia Caminiti, Rita Serra, Claudio Iovino, Enrico Peiretti; OCT angiography findings in Autosomal Dominant Drusen patients. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1688.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate optical coherence tomography angiography (OCT-A) findings in eyes with Autosomal Dominant Drusen.
12 eyes of 6 patients (3 men and 3 women) with a clinical diagnosis of Autosomal Dominant Drusen underwent a complete ophthalmological examination including color fundus picture, fundus autofluorescence (FAF), fluorescein angiography (FA) and indocyanine green angiography (ICGA); enhanced-depth imaging optical coherence tomography (EDI-OCT) (HRA+OCT Spectralis Heidelberg), and OCT-A using AngioVue technologies (Optovue Inc). BCVA was also evaluated and any visual complain was recorded.
The mean age of the patients was 51 years. BCVA ranged from 1.77 LogMAR and 0 LogMAR (mean value 0.27 logMAR) and visual complaints were referred in 4 patients. On FAF, 6 eyes (50%) showed the presence of some area of hypoautofluorescence suggestive for geographic atrophy (GA) corresponding to some alteration of the ellipsoid/RPE zone on SD-OCT.In all eyes, choriocapillaris segmentation of OCT-A revealed different degrees of choriocapillaris impairment. Particularly, choriocapillaris was classified as rarefied in 8 eyes (66.6%) and absent in 4 eyes (33.3%). One eye showed the presence of a neovascular network on OCT-A better highlighted in the choriocapillaris segmentation.
OCT-A appears to be a valid instrument in order to follow the patients affected by Autosomal Dominant Drusen especially in the early stages of the disease before any visual complain.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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