Comparison between wide angle OCT angiography and ultra-wide field fluorescein angiography on the detection of non-perfusion area

Abstract

Purpose : Fluorescein angiography is valuable for the detection of non-perfusion area (NPA), but it is an invasive test. While OCT angiography (OCT-A) is a non-invasive test, the angle was narrow to detect NPA. We compared wide angle OCT angiography with ultra-wide field FA on the defection of NPA.

Methods : Patients with diabetic retinopathy (age ≥ 20 years, type 1 or type 2 diabetes mellitus) underwent nonsteered ultra-wide field FA using the Optos® panoramic 200Tx imaging system and wide angle OCT-A with 12.0x12.0-mm fields of five visual fixations (center, superotemporal, inferotemporal, superonasal, inferonasal) using PLEX Elite 9000®. We counted the numbers of the eyes of positive or false negative with OCT-A among eyes with positive NPA in FA and false positive or negative with OCT-A among eyes with NPA negative with FA. We calculated the sensitivity and the specificity for the detection of NPA by OCT-A.

Results : We evaluated twenty three eyes out of 13 patients (mean age, 59.9 years old; female/male, 5/8) with diabetic retinopathy. The number of true positive was 20 eyes; false negative, one eye; false positive, one eye; and true negative, one eye on the detection of NPA by OCT-A. The sensitivity for the detection of NPA by OCT-A was 0.95 and the specificity was 0.5.

Conclusions : Because the wide angle OCT-A with a 12x12 mm field has high sensitivity for the detection of NPA, it could replace FA.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.