June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Review of Clinical and Histopathological Features of Solitary Fibrous Tumor
Author Affiliations & Notes
  • Ryo Baba
    Ophthalmology, Tokyo Medical University, Shinjyukuku, Japan
  • Kazuhiko Umazume
    Ophthalmology, Tokyo Medical University, Shinjyukuku, Japan
  • Shunichiro Ueda
    Ophthalmology, Tokyo Medical University, Shinjyukuku, Japan
  • Hiroshi Goto
    Ophthalmology, Tokyo Medical University, Shinjyukuku, Japan
  • Footnotes
    Commercial Relationships   Ryo Baba, None; Kazuhiko Umazume, None; Shunichiro Ueda, None; Hiroshi Goto, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1802. doi:
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      Ryo Baba, Kazuhiko Umazume, Shunichiro Ueda, Hiroshi Goto; Review of Clinical and Histopathological Features of Solitary Fibrous Tumor. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1802.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Solitary fibrous tumor (SFT) is a rare, benign, spindle cell tumor that is most commonly found in the visceral pleura. The orbit is one of the common extrapleural sites of occurrence. We report 12 cases of orbital SFT with clinical data and histopathological features.

Methods : Twelve patients with SFT diagnosed and treated at Tokyo Medical University Hospital between 2003 and 2015 were reviewed. We retrospectively studied patient’s background initial symptoms, tumor location, prognosis and histopathology including immunohistochemistry.

Results : The 12 patients comprised 4 males and 8 females with mean age of 42.8 years (range: 14-78 years). Initial symptoms were diplopia (n=4), lid swelling (n=3), ptosis (n=3) and entropion (n=1), respectively. Tumor arose at supero-temporal quadrant (n=4), supero-nasal quadrant (n=3), retrobulbar (n=3), infero-temporal quadrant (n=1). Total resection was performed in all cases, and one case required re-operation due to recurrence. Immunohistochemical study revealed that STAT6 which is known as a transcriptional activator of SFT was positive in all 12 cases. CD34 and S-100 protein were also positive in 12 cases and 3 cases, respectively.

Conclusions : SFT can arise in various site in the orbit. Orbital SFT is more commonly seen in middle-aged patients, although it can also affect young children. SFT should be carefully monitored after complete excision, because it can potentially recur. Immunohistochemical staining of STAT6 and CD34 are critical for the histopathological diagnosis of SFT.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.


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