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Chrysoula Koutsiouki, Angela L Rees, Carlos Pavesio, Mark C Westcott; Retinal Microvasculature changes in Birdshot Retinochoroiditis (BRC) detected by Optical Coherence Tomography Angiography . Invest. Ophthalmol. Vis. Sci. 2017;58(8):2161. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate microvasculature changes of the superficial (SCP) and deep (DCP) capillary plexus in patient with BRC using Optical Coherence Tomography Angiogra (OCTA) .
Retrospective study of 22 eyes of 11 patients (7 females ,4 males) diagnosed with BRC compared with 10 control eyes attending a tertiary referral centre (Moorfields Eye Hospital, London, UK).All the BRC patients were HLA-A29 positive and underwent imaging using Angio Vue OCTA device (Optovue, Inc, Freemont, CA) with a 3X3mm and 6x6mm OCTA images of the posterior pole. Spectral domain optical coherence tomography ( Topcon or Spectralis) was performed concurrently.
The mean age was 58 years (range: 42 to 71years) . 10 patients were treated with systemic immunosuppression or intraocular steroid implants (Dexamethasone and Fluocinolone Acetonide). One patient was not on immunosuppressive treatment. 10 eyes had active disease. Widening of intercapillary spaces, compared with control eyes, in both SCP and DCP was observed in all BRC eyes. This was more pronounced in the DCP compared with the SCP. In 3 eyes black oblong areas of flow voids were observed in areas corresponding to the cystoid macular oedema (CMO) on the B-scan. In BRC, CMO was mostly located on the DCP and enFace structural OCT image showed the distribution of the oedema. Enface of the SCP showed the presence of retinal vessel traction corresponding to the presence of epiretinal membrane on the SD-OCT in 3 eyes. OCTA of SCP showed capillary dilations in 18 eyes and capillary loops in 2 eyes. In one eye, OCTA identified blood flow at the level of the outer retina and a hyperreflective lesion at the choriocapillary level, consistent with choroidal neovascularization
This study characterises OCTA changes on the SCP and on the DCP in the BRC patients. The microvasculature changes on the BRC could be secondary to the inflammatory process along with the ischemic changes noticed on the SCP and DCP. It remains to be seen if the OCTA findings could be used as prognostic factors and for the monitoring of BRC
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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