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Ryosuke Matsushima, Yoshihiko Usui, Takeshi Kezuka, Kinya Tsubota, Akihiko Umazume, Naoyuki Yamakawa, Yoshihiro Wakabayashi, Hiroshi Goto; Analysis of IL-10 in the intraocular fluids of patients with infectious uveitis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2180. doi: https://doi.org/.
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The measurement of vitreous interleukin-10 (IL-10) is critical for the diagnosis of intraocular lymphoma. On the other hand, IL-10 may have an inhibitory effect in infectious immunity. In this study, we measured and analyzed the concentration of IL-10 in the intraocular fluids obtained from various patients with infectious uveitis.
Aqueous humor or vitreous humor were collected from 31 eyes of acute retinal necrosis (ARN), 13 eyes of bacterial endophthalmitis, 6 eyes of fungal endophthalmitis, 9 eyes of VZV-related iridocyclitis, 3 eyes of toxoplasma chorioretinitis, 30 eyes of intraocular lymphoma, 26 eyes of patients with epiretinal membrane or macular hole, and 22 eyes of cataract,. The concentration of IL-10 was measured by Cytometric Bead Array Flex kitR.
The concentration of IL-10 collected from vitreous humor in bacterial endophthalmitis, funｇal endophthalmitis, ARN and toxoplasma chorioretinitis were significantly higher than that of patients with epiretinal membrane or macular hole, and significantly lower than that of intraocular lymphoma. The concentration of IL-10 collected from aqueous humor in ARN and VZV-related iridocyclitis were significantly higher than that of cataract. IL-10 in the aqueous humor collected from patients with cataract and that in the vitreous humor collected from patients with epiretinal membrane and macular hole were undetactable.
A certain concentration of IL-10 was detected in infectious uveitis irrespectively of causative microorganism. It is suggested that IL-10 is related to the infectious immunity.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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