Abstract
Purpose :
To assess the relationship between self-reported uveitis in patients with diagnosed arthritis and purported demographic and clinical risk factors, of a population extracted from the National Health and Nutrition Examination Survey (NHANES).
Methods :
For our study we used the NHANES database of the Centers for Disease Control and Prevention (CDC) for the year 2009-2010. A national representative sample of 5,106 subjects diagnosed with arthritis, extracted from a pool of 10,537 patients, were asked if they had ever been diagnosed with uveitis. The demographic analysis included age, gender and ethnicity. The main outcome was the presence of uveitis. Potential predictors were type of arthritis, history of smoking and mental health measures. Univariate and multivariate analyses were conducted using RStudio (Version 0.99.903, RStudio, Inc., Boston, MA).
Results :
Of the 5,106 participants with arthritis, 27 had reported a diagnosis of uveitis and 19 received ophthalmological treatment. Among those patients with self-reported uveitis, 73% were female and 37% male, and the mean age was 52.8 ± 13 years. The distribution of ethnicity was 29.6% Hispanic, 37.1% non-Hispanic white, 22.2% non-Hispanic black and 11.1% others. Positive smoking history was reported in 59.2% of the patients, the univariate analysis comparing smoking with the presence of uveitis in the arthritis population showed an OR of 1.82 (95% CI 1.11-2.96; p=0.02) and the multivariate analysis adjusting for age and gender showed an OR of 3.18 (95% CI 1.59-6.37; p=0.003). A greater age was correlated with higher uveitis prevalence (OR = 1.04, 95% CI 1.01-1.07; p=0.02). Additional analyses were performed regarding different types of arthritis (rheumatoid arthritis, osteoarthritis and psoriatic arthritis) and mental health status (anxiety and depression) and there was no correlation with uveitis.
Conclusions :
Our study has found that smoking and age are positively correlated with the diagnosis of uveitis in the arthritis cohort of a population-based study and that may be risk factors for the prevalence of this disease, which can have clinical relevance since smoking is a modifiable habit.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.