June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Effect of crystalline lens’ aberrations on AO-simulation of IOLs in phakic eyes
Author Affiliations & Notes
  • Silvestre Manzanera
    Laboratorio de Optica, University of Murcia, Murcia, Spain
  • Carmen Maria Lago
    Laboratorio de Optica, University of Murcia, Murcia, Spain
  • Lucia Hervella
    Voptica, Murcia, Spain
  • Lucie Sawides
    Laboratorio de Optica, University of Murcia, Murcia, Spain
  • Eloy Villegas
    Laboratorio de Optica, University of Murcia, Murcia, Spain
  • Pablo Artal
    Laboratorio de Optica, University of Murcia, Murcia, Spain
  • Footnotes
    Commercial Relationships   Silvestre Manzanera, Voptica (I); Carmen Lago, None; Lucia Hervella, Voptica (E); Lucie Sawides, None; Eloy Villegas, Voptica (I); Pablo Artal, Voptica (I)
  • Footnotes
    Support  European Research Council Advanced Grant ERC-2013-AdG-339228 (SEECAT); SEIDI, Spain (grant FIS2013-41237-R); “Fundación Séneca,” Murcia, Spain (grant 19897/GERM/15)
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2497. doi:
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      Silvestre Manzanera, Carmen Maria Lago, Lucia Hervella, Lucie Sawides, Eloy Villegas, Pablo Artal; Effect of crystalline lens’ aberrations on AO-simulation of IOLs in phakic eyes. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2497.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Adaptive optics visual simulators (AOVS) allow the prediction of visual outcomes with intraocular lenses (IOL) before the actual cataract surgery is performed. The effective phase profile of the IOL is induced in the phakic eye and visual performance is measured. While in this case the retinal image is affected by the cornea, lens and the induced IOL, after surgery the lens will not be present. In this context, we evaluate the impact of the lens’ aberrations on the AO simulation of IOLs in phakic subjects.

Methods : The experiment was performed monocularly using our AOVS laboratory prototype in 5 subjects. For each eye, the aberrations of the cornea and the whole eye were first measured and the lens’ aberrations estimated by direct subtraction. Visual acuity (VA) at best focus and two different contrasts (100% and 20%) was measured for 5 different conditions. The case with natural lens’ aberrations (case Natural), when the spherical aberration (SA) of the lens was either corrected (case –SA) or doubled (case +SA), and with all high order aberrations of the lens corrected (case –WA) or doubled (case +WA). Through-focus high contrast VA was also measured for a diffractive IOL for the cases ‘Natural’ and ‘-WA’. Three different pupil sizes, 3, 4.5 and 6 mm were tested for all conditions.

Results : In average, for the 4.5 mm pupil high contrast VA was found to be similar for all tested cases. The changes with respect to the Natural case were 0.00±0.20 (case -SA), 0.01±0.22 (case -WA), -0.02±0.17 (case +SA) and 0.04±0.24(case +WA) units of LogMAR. Observed differences were similar for the 3 and 6 mm pupils except for case ‘+WA’ at the largest pupil with a difference of 0.08±0.23 units of LogMAR. For low contrast VA the absolute values of the differences were in average double than those found for high contrast but resulting in p<0.05 only for cases ‘+WA’ (4.5, 6 mm) and ‘-WA’ (3, 4.5 mm pupil). There were no differences in the measurements with the diffractive IOL profile for all the conditions.

Conclusions : Lens’ aberrations in phakic eyes play a minor role in the AO visual simulation of IOLs. AOVS can be accurately used prior to cataract surgery to predict future visual outcomes. In some special cases, the particular aberrations of the lens should be subtracted when inducing the IOL phase for an even better prediction.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.


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