Abstract
Purpose :
To evaluate the correlation of ganglion cell-inner plexiform (GC-IPL) thickness with area of foveal avascular zone (FAZ) using OCTA in diabetic eyes
Methods :
Medical records of diabetic patients without retinopathy (n=40), diabetic patients with mild to moderate NPDR (n=60), and healthy eyes (n=40) were reviewed. The mean parafoveal GC-IPL thickness were measured using Cirrus HD-OCT (Carl Zeiss). The FAZ area in the superficial and deep plexus layers were measured and evaluated using OCT angiography (Angioplex, Carl Zeiss)
Results :
The FAZ area in the superficial and deep capillary plexus layer was 0.31±0.10mm2, 0.39±0.11mm2 in healthy eyes, whereas 0.39±0.13mm2, 0.46±0.14mm2 in diabetic eyes without retinopathy and 0.37±0.15mm2, 0.44±0.12mm2 in eyes with diabetic retinopathy. Diabetic eyes showed statistically significant FAZ enlargement in both superficial and deep layer compared with healthy eyes. The FAZ area and GC-IPL thickness were significantly correlated in both diabetic groups (p=0.03, p<0.001), whereas it was not significant in control (p=0.894)
Conclusions :
Both enlargement of FAZ and retinal neurodegneration occurs in early diabetic retinopathy regardless of presence of retinopathy. Also, FAZ area and GC-IPL thickness were numerically correlated in diabetic eyes
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.