June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Risk factors for recurrences in central serous chorioretinopathy
Author Affiliations & Notes
  • Alexandre Matet
    Jules-Gonin Eye Hospital, Lausanne, Switzerland
  • Alejandra Daruich
    Jules-Gonin Eye Hospital, Lausanne, Switzerland
  • Marta Zola
    Jules-Gonin Eye Hospital, Lausanne, Switzerland
  • Francine F Behar-Cohen
    Jules-Gonin Eye Hospital, Lausanne, Switzerland
  • Footnotes
    Commercial Relationships   Alexandre Matet, None; Alejandra Daruich, None; Marta Zola, None; Francine Behar-Cohen, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2965. doi:
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      Alexandre Matet, Alejandra Daruich, Marta Zola, Francine F Behar-Cohen; Risk factors for recurrences in central serous chorioretinopathy
      . Invest. Ophthalmol. Vis. Sci. 2017;58(8):2965.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To describe recurrence patterns and investigate candidate risk factors for recurrences after acute central serous chorioretinopathy (CSCR).

Methods : For this observational case series, systemic and multimodal imaging parameters influencing recurrences in 52 patients with acute CSCR were evaluated using a frailty Cox proportional hazard survival model. The evaluated covariates included systemic findings: age, gender, treatment, duration of previous episode, history of corticosteroid use, stress, shift work, sleep disorder, depression, allergy, and cardiovascular risk (hypertension/dyslipidemia); optical coherence tomography (OCT) findings: subfoveal choroidal thickness (SFCT), irregular pigment epithelial detachment (PED), number of subretinal hyperreflective foci at leakage site; angiographic findings: intense leakage on fluorescein angiography, multifocal choroidal hyperpermeability on indocyanine-green angiography.

Results : Twenty-five of 52 subjects (48%) presented ≥1 recurrences during a mean follow-up of 29±10 months [range, 12-54 months]. Follow-up duration did not differ between cases with or without recurrences (P=.4). Worse visual acuity levels (logarithm of the minimal angle of resolution) were associated with higher number of episodes during follow-up (P=.009, r=.36). In a univariate analysis, higher SFCT (P=.019), irregular PED (P=.047), multiple subretinal hyperreflective foci on OCT (P=.011), and shift work (P=<.0001) were significantly associated with recurrences, with a near-significant influence of non-intense fluorescein leakage (P=.054) and allergy (P=.073). In a multivariate analysis, higher SFCT (P=.017), non-intense fluorescein leakage (P=.016) and shift work (P=.0003) remained significant and independent risk factors for recurrences.

Conclusions : These results contribute to identify CSCR patients at higher risk of recurrence, who could benefit from earlier and/or more intensive therapeutic intervention.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.


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