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Tomofumi Tani, Young-Seok Song, Kenji Sogawa, Taknari Wada, Akihiro Ishibazawa, Tsuneaki Omae, Eiichi Sato, Shunsuke Nakamura, Jun Sakai, Masahiro Akiba, Takafumi Yoshioka, Akitoshi Yoshida; Retinal circulation changes with aging effect in normotensive healthy subjects. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3040.
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© ARVO (1962-2015); The Authors (2016-present)
To report the effects of aging on the retinal microcirculation using a newly developed Doppler optical coherence tomography (OCT) auto-flowmeter (Auto-DOCT) in healthy male subjects.
We measured the retinal arterial blood flow in 33 healthy male volunteers (age; 21 to 68). The auto-DOCT system is based on spectral-domain OCT with fully automated measurement functionality. We measured blood velocity (V) and calculated the retinal pulsatility ratio (PR) in the retinal temporal arteries. PR is expressed as PSV/EDV, where PSV is the peak velocity during systole and EDV is the end diastolic velocity. Typically, an increased PR is an indicator of increased vascular resistance to flow and/or decreased vascular compliance, distal to the measurement site. Pearson's correlation analysis was used to determine whether PR was correlated with the aging.
The PR showed strong correlation with age (r=0.62, p<0.0001), suggesting that the increased blood flow pulsatility in the retinal arteries with healthy male subjects is due to normal aging.
The current study showed that the auto-DOCT enables estimation of vessel aging from the measurements of retinal arterial blood flow in normotensive healthy humans.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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