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Kunho Bae, Eung-Suk Kim, Jae Min Kim, Se Woong Kang, Seung-Young Yu; Five-year outcomes of Polypoidal Choroidal Vasculopathy in Unaffected fellow eyes. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3206.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the incidence of polypoidal choroidal vasculopathy (PCV) or choroidal neovascularization (CNV) in the fellow eyes of patients with unilateral PCV and to identify the ocular risk factors related to development of neovascular changes in the fellow eyes of patients with unilateral PCV.
We retrospectively reviewed the medical records of 48 patients with unilateral PCV, all of whom had completed at least 60 months of follow-up. All patients underwent complete ophthalmologic examination, fundus photography, and optical coherence tomography. The angiographic features were evaluated including the development of active PCV over time, choroidal vessel dilation, choroidal vascular hyperpermeability, and branching vascular network (BVN) on indocyanine green angiography (ICGA).
The mean follow-up period was 73.10±14.33 months. Among 48 fellow eyes, 10 (20.8%) had drusen, 19 (39.6%) had choroidal thickness>200um, 9 (18.8%) had retinal pigment epitheliopathy, 9 (18.8%) had irregular RPE elevation, 13 (27.1%) had choroidal vascular dilation, 12 (25%) had choroidal vascular hyperpermeability, 9 (18.8%) had BVN. The development of active PCV and CNV was noted in 8 fellow eyes (17%). The presence of choroidal thickness>200um(p=0.002), irregular RPE elevation(p<0.001), choroidal vascular dilation(p<0.001), choroidal vascular hyperpermeability(p<0.001), BVN(p<0.001) in the fellow eye had stastically significant correlation with development of PCV (Examined with Fisher’s exact test). In multivariate regression, BVN on IGGA(P=0.045, OR=24.66) in the fellow eye was a significant risk factor for the development of PCV or CNV (Examined with Logistic regression).
PCV or CNV was developed in 17% of fellow eyes during the follow-up period (≥ 60 months). The presence of choroidal thickness>200um, irregular RPE elevation, choroidal vascular dilation, choroidal vascular hyperpermeability, BVN in the fellow eye appears to be a significant associated factors with the development of PCV or CNV in fellow eyes. Because BVN on IGGA in the fellow eye was a significant risk factor for the development of PCV or CNV, PCV patients with contralateral BVN is recommended more close follow up for future development of PCV or CNV in fellow eyes.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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