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Alison Early, Thomas Mauger, Craig Miller, Sarah Adelson; The relationship of cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3344.
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To evaluate smoking and alcohol use as risk factors for higher grade dysplasia in a population of patients with histopathologically proven ocular surface squamous neoplasia.
Retrospective chart review of data extracted from a database comprised of demographic information and medical diagnosis information based on International Classification of Disease (ICD-9) codes. Outcome measures were analyzed using the Wilcoxon two-sided test, a non-parametric t-test.
Database review yielded 35 patients with OSSN lesions proven by histopathological analysis. The mean age was 64.51 years with standard deviation 17.54 years. Patients were 28.57% female and 71.43% male. Nearly all patients were White (88.57%), with 5.71% African American, 2.86% Hispanic, and 2.86% Other. There was no significant difference in dysplasia grade between smokers and non-smokers (p=0.7044), those who use alcohol versus do not use alcohol (p=0.2470), those who use tobacco and alcohol versus those who do not (p=0.5117), and who use either tobacco or alcohol versus those who do not (p=0.8259).
No statistically significant relationship was found between high grade dysplasia and cigarette smoking, alcohol use, or both cigarette smoking and alcohol use.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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