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Robert Herber, Eberhard Spoerl, Frederik Raiskup, Lutz E Pillunat; Effects of beam profile settings for corneal cross-linking in progressive keratoconus: 3-year-follow-up.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3503. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
The aim of this study was to evaluate the effects of high intensity corneal cross-linking (CXL) with optimized beam profile setting performed with UV-X 2000 (AVEDRO, Massachusetts, USA) in comparison with a standard top-hat profile, based on corneal topographic and tomographic parameters.
37 eyes of 37 patients with progressive keratoconus were treated between 2010 to 2013. The follow-up time was 36 month postoperatively. Group 1 included 18 eyes (age 31.7±9.9 years) which were treated with standard top-hat profile (TH). Group 2 included 19 eyes (age 33.5±11) which received a treatment with optimized beam profile (BO). The cross-linking was performed based on the modified Dresden protocol with a shorter irradiation time (10 min) and a higher energy (9 mW/cm2). The topographic and tomographic parameters were recorded by the Pentacam (OCULUS, Wetzlar, Germany).
Keratometry at the apex (Kapex) decreased significantly from 56.46±6.86 D to 52.77±7.33 D (P=0.001) by TH-profile and from 53.73±4.44 D to 51.72±3.8 D (P=0.000) by BO profile three years after CXL. There was also a significant reduction at the flat (PTH=0.006, PBO=0.037) and steep (PTH=0.006, PBO=0.019) keratometry. The corneal thickness was significantly lower after the treatment and did not reached the baseline values (TH: -25.61±42.57 µm, P=0.005 and BO: -11.79±18.9 µm, P=0.017).
The corneal topography improved significantly after CXL in both groups, whereas the beam profiles did not distinguish from each other regarding the treatment effects.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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