Total, corneal, and internal high order aberrations in monocular diplopia patients without anterior segment abnormality

Abstract

Purpose : To evaluate the optical performance and wavefront profiles in the eyes presenting monocular diplopia without cornea and lens abnormalities

Methods : This retrospective study included 27 eyes of 16 patients who presented monocular diplopia with no apparent corneal abnormalities on slit lamp examination. Patients were subclassified into Clear lens group (16 eyes of 8 patients) and Haze lens group (12 eyes of 8 patients) according to the lens status on slit lamp biomicroscopy. Total high order aberration (HOA), coma, and trefoil up to 6th order in internal, corneal, and total optical path difference (OPD), and Strehl ratios at mesopic condition and at 5 mm pupil size were evaluated using OPD-Scan III.

Results : The average age was 35.3 ± 19.7 (23.3 ± 12.3 with Clear lens group and 51.2 ± 16.3 with Haze lens group, p < 0.001). Although there was no apparent abnormalities in cornea and lens on slit lamp examination, clear lens group showed increased root mean square (RMS) of HOA (0.571 ± 0.294, reference value 0.32 ~ 0.42) and decreased Strehl ratio (-2.900 ± 0.278 by natural logarithm, reference value -2.60 ~ -1.90). There was no significant difference between Clear lens group and Haze lens group in all parameters except in the trefoil and HOA values of the total OPD in the condition with 5 mm-sized pupil (p=0.030 and p=0.028 respectively). However, the HOAs of mesopic pupil were significantly higher than the HOAs of 5 mm pupil (p=0.002 in total, p=0.003 in corneal, p=0.003 in internal OPD) in Clear lens group.

Conclusions : The results suggest that the relative increase of HOA in the mesopic condition may induce monocular diplopia in the eyes without apparent anterior segment abnormality.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.