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Signe Krejberg Jeppesen, Toke Bek; Lack of predictive value of retinal oxygen saturation for visual outcome after anti-VEGF treatment in central retinal vein occlusion. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3656.
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© ARVO (1962-2015); The Authors (2016-present)
Occlusion of the central retinal vein (CRVO) is a frequent cause of visual loss. The severity of ischaemia in CRVO can be studied by fluorescein angiography, but measures of visual function have been shown to be superior for predicting the visual prognosis in CRVO. Previous studies have shown that the oxygen saturation in retinal veins is reduced in patients with CRVO, but the predictive value of retinal oxygen saturation for visual outcome in patients with CRVO has not been studied in detail.
Retinal oximetry was performed in 91 consecutive patients with CRVO (age 70.8, 28-96 years) (mean, range) in one eye referred to the Department of Ophthalmology, Aarhus University Hospital, and the predictive value of the retinal oxygen saturation in larger retinal vessels for the visual prognosis after three monthly intravitreal injections with anti-VEGF medication was studied.
At baseline the oxygen saturation in larger retinal vessels was significantly higher for arterioles and significantly lower for venules in the affected (100.7±1.4 % for arterioles and 37.8±2.6 % for venules) than in the unaffected eye (96.3±0.6 for arterioles and 58.2±1.3 for venules), p<0.001 for both comparisons. The best corrected visual acuity (BCVA) showed a significantly negative correlation with the oxygen saturation in retinal arterioles (p=0.002) and a significantly positive correlation with the oxygen saturation in retinal venules (p=0.013). A multiple linear regression model shows that BCVA, but not oxygen saturations or any of the other included explanatory variables at baseline contributed significantly to predicting visual outcome after treatment.
Retinal oximetry cannot replace measures of retinal function as the best predictive parameter for the visual outcome in CRVO after three intravitreal anti-VEGF injections. However, the correlation between retinal oxygen saturation and BCVA at the time of diagnosis of CRVO may help understanding haemodynamic and visual changes in the acute stages of the disease.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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