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Yih Chung Tham, Charumathi Sabanayagam, Tin Aung, Tien Wong, Ching-Yu Cheng; Relationship between Glomerular filtration rate and Primary Open-Angle Glaucoma: the Singapore Chinese Eye Study. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3722.
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Systemic microvascular dysfunction has been suggested to contribute to the development of primary open-angle glaucoma (POAG). Impaired renal function is an indicator of systemic microvascular damage. However, the relationship between renal function and POAG is not well understood. In this study, we aimed to investigate the relationship between estimated glomerular filtration rate (eGFR) and POAG in an adult chinese population.
Participants of the Singapore Chinese Eye study underwent standardised ocular and systemic examinations. eGFR was measured from serum creatinine and quantified in units of ml/min/1.73m2. POAG was diagnosed using the International Society of Gepgraphic and Epidemiological Ophthalmology classification. The association between eGFR and POAG was evaluated using logistic regression models. Generalised estimating equation models were used to account for correlation between both eyes.
A total of 3,191 chinese adults aged 40 to 80 from the Singapore Chinese Eye Study were included in this study. Of which, 55 subjects (78 eyes) had POAG. After adjusting for age, gender, hypertension, diabetes, body mass index, total cholesterol level and intraocular pressure, lower eGFR (per 10 ml/min/1.73m2 decrease) was independently associated with POAG (odds ratio [OR]= 1.18; 95% confidence interval [CI]= 1.01 to 1.37; P=0.033). Further stratification of eGFR levels showed that, individuals with normal level of eGFR levels (≥90 ml/min/1.73m2) were 4.97 times (95% CI, 1.49 to 16.59; P=0.009) likely to have POAG, compared to those with low levels of eGFR levels (<45 ml/min/1.73m2). The significant association between lower eGFR and POAG was observed among diabetics (OR = 1.36; 95% CI, 1.13 to 1.63; P=0.001) but not in non-diabetic individuals (OR = 1.03, P=0.772).
Our population-based study in Chinese adults showed that lower levels of eGFR which is indicative of poorer kidney function, was independently associated with POAG. This finding potentianlly suggests that targetted glaucoma screening among individuals with kidney disease is important.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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