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Rebecca Janet Salowe, Laura O'Keefe, Sayaka Merriam, Roy Lee, PRITHVI SANKAR, Eydie G Miller-Ellis, Amanda Lehman, Victoria Addis, Windell Murhpy, Jeffrey D Henderer, Maureen G Maguire, Joan M O'Brien; Supplemental Recruitment Methods for the Primary Open-Angle African American Glaucoma Genetics Study. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3736. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Though African Americans have been historically under-represented in genetic studies, little research has examined the most effective recruitment strategies for this population. This study evaluates the cost and efficacy of four supplemental recruitment methods employed by the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study.
After enrolling 2427 patients from University of Pennsylvania ophthalmology clinics, the POAAGG study implemented four new recruitment methods to supplement clinic enrollment. These methods included: 1) outreach to the local community, 2) in-house screening of community members (“in-reach”), 3) expansion to two external sites, and 4) sampling of the Penn Medicine Biobank. The cost per subject was calculated for each method and enrollment among cases, controls, and suspects was reported.
Biobanks offered the lowest cost ($4.76/subject) and highest enrollment yield (n=1973) of the four methods, but provided very few glaucoma cases (n=26). External sites provided 89.6% of cases recruited from the four methods (n=383), but case enrollment at these sites declined after a cycle of two to three patient appointments (~6-8 months). Outreach and in-reach screenings of community members were very high cost for low return on enrollment ($569.28/subject for 102 subjects and $605.59/subject for 45 subjects, respectively). This last effort required philanthropic support.
Biobanks offered the most cost-effective method for control enrollment, while expansion to external sites was necessary to recruit richly phenotyped cases. These recruitment methods helped the POAAGG study to exceed enrollment of the discovery cohort (n=5500) six months in advance of the predicated deadline and can be adopted by other large genetic studies seeking to supplement clinic enrollment.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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