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Kirsten Anderson, Anne Stewart Gority Irvine, Jack J Tian, Kenneth L Lu, Stuart G Coupland, Rustum Karanjia, Alfredo A. Sadun; Using pattern ERG to objectively measure contrast sensitivity associated with intraocular lenses.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4276.
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© ARVO (1962-2015); The Authors (2016-present)
The purpose of this study is to use pattern ERG (pERG) to quantify the changes in contrast sensitivity (CS) when mono- and multifocal intraocular lenses (IOLs) are placed in front of young, healthy eyes.
Five patients with a mean age of 25 years with healthy eyes refractable to a visual acuity (VA) of 20/20 and without ocular disease were tested an ISCEV compliant 0.75 CPD pERG protocol at different contrast intensities (Espion E3; Diagnosys LLC, Lowell, MA). Six different contrast intensities (100%, 95%, 90%, 85%, 80%, and 75%) were tested under four different paradigms. In each paradigm the subject was corrected to 20/20 using spectacle correction. Baseline recordings were obtained from each subject with two testing paradigms; B1. Without the IOL lens holder, B2. With the IOL lens holder but no IOL. Experimental recordings were done using two different testing paradigms; E1. With a monofocal IOL; E2. With a multifocal IOL. Data was averaged for all 5 test subjects. An unpaired students t-test was used to compare data sets.
Decreasing contrast produced decreased amplitude of the N95 wave in eyes corresponding to the retinal ganglion cell function, at a single stimulus gradient in all four testing paradigms. There was no difference between the amplitude of the N95 wave for paradigms B1, B2 and E1 (p>0.05). There was a significant decreased in the N95 amplitude for the between testing paradigms E1 (monofocal IOL) and E2 (Multifocal IOL) of 38% at 100% contrast (p<0.02). Similar findings were found across all contrast intensities with a decrease in the N95 amplitude from 35% to 22% between the E1 and E2 paradigms.
We found that all lenses placed in front of healthy, young eyes resulted in a decrease in N95 amplitude; the decrease was more profound in multifocal IOLs. This information should be considered clinically in IOL and candidate selection.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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