June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Efficacy of Repeated LipiFlow Treatment for Obstructive Meibomian Gland Dysfunction
Author Affiliations & Notes
  • Reiko Arita
    Itoh Clinic, Bunkyo-ku, Japan
    Lid and meibomian gland working group, Tokyo, Japan
  • Shima Fukuoka
    Omiya Hamada Eye Clinic West Branch, Saitama, Japan
    Lid and meibomian gland working group, Tokyo, Japan
  • Naoyuki Morishige
    Oshima Eye Hospital of Ophthalmology, Fukuoka, Japan
    Lid and meibomian gland working group, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Reiko Arita, TearScience (F), TOPCON (P); Shima Fukuoka, None; Naoyuki Morishige, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4380. doi:
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    • Get Citation

      Reiko Arita, Shima Fukuoka, Naoyuki Morishige; Efficacy of Repeated LipiFlow Treatment for Obstructive Meibomian Gland Dysfunction. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4380.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : LipiFlow (TearScience, Morrisville, NC) is a device for treatment of meibomian gland dysfunction (MGD) based on warming and massage of the eyelid. Given that we found that some MGD patients treated with a single application of LipiFlow did not show improvement in their symptoms, we evaluated the clinical efficacy of repeated LipiFlow treatment in such individuals.

Methods : Among 30 patients with obstructive MGD subjected to a single application of LipiFlow, 10 individuals (7 women and 3 men; mean age ± SD, 48.4 ± 16.4 years; age range, 30 to 88 years) who did not show improvement in their subjective symptom score, lid margin findings (such as plugging, vascularity, and irregularity), and meibum grade were enrolled in the present study. For examination of the effects of repeated LipiFlow treatment, LipiFlow was applied to both eyes of each subject three times every 3 months. We evaluated the clinical parameters in right eye such as lid margin abnormalities, the thickness of the lipid layer of the tear film, tear film breakup time, meibum grade, epithelial disorders, meiboscore (as determined by meibography), and the Schirmer test value as well as the subjective symptom score before the initial application of LipiFlow and 1 month after each treatment application.

Results : The study subjects included 5 individuals with MGD combined with aqueous-deficient dry eye, 5 individuals with a history of contact lens wear, and 6 individuals with extensive damage to MG morphology. The subjective symptom score was significantly improved (P = 0.006) after the second application of the study treatment. Furthermore, the subjective symptom score, lipid layer thickness, tear film breakup time, and meibum grade were significantly improved after the third application (P < 0.001, P < 0.001, P < 0.001, and P = 0.019, respectively).

Conclusions : LipiFlow treatment requires repeated application to show efficacy in some MGD patients. Such repeated application is thus a promising option for treatment of refractory MGD.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.


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