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Giorgio Panozzo, Eleonora Corbelli, alessandro marchese, Adriano Carnevali, Maria Vittoria Cicinelli, Michele Cavalleri, Lea Querques, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques; OCT-ANGIOGRAPHY OF QUIESCENT CNV IN ANGIOID STREAKS. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4636.
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© ARVO (1962-2015); The Authors (2016-present)
Choroidal neovascularization (CNV) is by far the most common cause of visual loss in patients affected by angioid streaks (AS). Optical coherence tomography angiography (OCT-A) is a new imaging technique able to detect treatment-naïve quiescent CNV along the AS. The aim of this study is to estimate the prevalence of treatment-naïve quiescent CNV in angioid streaks and to investigate their OCT-A features.
We retrospectively analyzed treatment-naïve subjects affected by AS without exudative choroidal neovascularization (CNV). All patients underwent standard multimodal imaging, including multicolor imaging, infrared retinography (IR), blue autofluorescence (BAF), fluorescence angiography (FA), structural OCT and OCT-A (Angioplex™, CIRRUS HD-OCT models 5000, Carl Zeiss Meditec, Inc., Dublin, USA). Then, we identified treatment-naïve CNV along AS and studied their OCT-A features.
We included 12 eyes of 6 subjects (5 males and 1 female, age 50±18 years) affected by AS. We analysed 27 angioid streaks by means of OCT-A. In seven out of 27 AS, choriocapillary segmentation of OCT-A revealed an irregular vascular network representing treatment-naïve quiescent CNV. Interestingly, they appeared on structural OCT as flat irregular elevation of the retinal pigment epithelium (RPE) with hyper-reflective accumulations above the Bruch’s Membrane (BM), without intra/subretinal hyporeflective fluid.
OCT-A is able to detect the presence of treatment-naïve quiescent CNV along AS, in areas of flat irregular elevation of the RPE as visualized by structural OCT.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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